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Our study showing that Omicron subvariants are even more capable than other VOCs in suppressing MHC I expression to evade CD8 T cell immunity is just published. Congratulations to Miyu Moriyama Carolina Lucas Valter Nathan Grubaugh & team 👏🏼 👏🏼 👏🏼 (1/) pnas.org/doi/10.1073/pn…

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent immune response against a distant tumor. Y. Erin Chen, MD PhD led the charge w/ help from Djenet Bousbaine, Alessandra Veinbachs, Belkaid Lab. Science Magazine 1/26 science.org/doi/10.1126/sc…

So pleased to report that our Mount Sinai-Yale long COVID (MY-LC) paper with @putrinolab & others is now published!! Proud of the hard work of all who contributed. We found biological signatures that can distinguish people with vs. without #longCOVID (1/) nature.com/articles/s4158…

Application advising for prospective applicants to Stanford Immunology! Spread the word to interested mentees!

With several recent advances and funding, Covid nasal vaccines now have momentum. It's covered in the new Ground Truths (link in my profile)

#WeekendRead! #TheMoreTheMerrier! Weichhart &co show Cell Metabolism that “macrophages act as commensals that provide metabolic support to promote efficient self-renewal of the colon epithelium” & that boosting polyamines via mTORC protect against colitis dlvr.it/SxCjVx

Why is SLE so predominantly a disease of women? One component is that XIST, a lncRNA involved in X inactivation and thus highly expressed in women, is a potent TLR7 activator. XIST knockdown reduces the TLR7 stimulation of total cellular RNA by quite a bit.

If you’re interested in host-microbiota interactions but like your microbes with membrane bound organelles then our paper on symbiotic protists is for you Cell . Congrats Elias Gerrick and a huge thank you to all our collaborators! cell.com/cell/fulltext/…

Beautiful microbial ecology to understand clinical microbiology. Microbiome diversity protects against pathogens by nutrient blocking | Science science.org/doi/10.1126/sc…

Congratulations to HHMI Investigator Ruslan Medzhitov, who has been awarded the 2024 National Academy of Sciences Jessie Stevenson Kovalenko Medal for foundational contributions to the understanding of innate immunity! Learn more: hhmi.news/3S8dGJl #NASaward

Excited to share our group's first manuscript describing new anatomical connections that allow the eyes to act as an "immunological window to the brain" 👁️🧠 (1/) nature.com/articles/s4158…

Online now: Intraepithelial mast cells drive gasdermin C-mediated type 2 immunity dlvr.it/T5VW5D

Huge congratulations to my former mentor Prof. Akiko Iwasaki for this well-deserved honor!! She inspires me beyond words as a scientist, communicator, woman, mother, advocate, and more— thank you Akiko!!!

Preventing infection is the best way to avoid diseases like #PAIS. A new study from our team Tianyang Mao, Jooyoung Kim, Mario Peña-Hernández 🦇 et al shows that a generic antibiotic neomycin acts on the host immune system in the👃🏽to trigger antiviral resistance. (1/)🧵

Excited to show our recent work regarding meningeal T regulatory cells and their role preserving hippocampus stem cells!

Extremely excited to see our paper out in nature! How does the body respond to SARS-CoV-2, and what happens if you don't get infected after exposure? We unravel the exact timeline of the cellular responses to inoculation with SARS-CoV-2 in humans. (1/4) nature.com/articles/s4158…

The final published version of our full-spike deep mutational scanning paper described in above thread is now out: nature.com/articles/s4158…

A new study led by Mario Peña-Hernández 🦇 in collaboration with the Craig Wilen examines two bat coronaviruses that are the closest relatives of SARS-CoV-2 for their ability to infect, evade immunity and transmit between rodents. Some key takeaway points 🧵 (1/) nature.com/articles/s4156…

Globally, millions of individuals are affected by endometrial / uterine disorders, yet the #endometrium and the role of its #cellular #heterogeneity in these disorders have been hugely understudied compared with other human tissues and diseases.

New paper out nature - why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? sex chromosomes or hormones? Here we studied adaptation of human immune systems to gender-affirming