lots of great #dementia work in this issues of the annals - onlinelibrary.wiley.com/toc/15318249/2… my highlight: onlinelibrary.wiley.com/doi/abs/10.100… shows tau in 'normal' aging accompanied by 'normal' atrophy; whereas in AD it comes well before atrophy @relajoie #Alzheimers #neuroscience #PET #tau

academic.oup.com/brain/advance-… in cognitively healthy elderly, #tau suvr + thickness of the entorhinal cortex are the strongest predictors of worse performance in memory tests pretty interesting results from a massive database Mayo Clinic Neuro Brain #dementia #Alzheimers

jamanetwork.com/journals/jaman… more evidence that women are affected differently in #dementia - #tau deposits occur earlier in the disease trajectory. important work by Rachel Buckley 🐨🇦🇺🐨 in JAMA Neurology excellent commentary (as usual) here: goo.gl/F2z7Va Women's Brain Foundation #Alzheimer

science.sciencemag.org/content/363/64… structural analysis of y-secretase for the first time shows specific binding of APP; reveals a common feature of AD #Alzheimer and might lead towards notch-sparing inhibitors pretty cool work in recent Science Magazine by Zhou #dementia #neurotwitter

doi.org/10.1016/j.stem… using #iPSC from #Alzheimer patients, @alzheimerondrzk + al show that targeting the cholesterol metabolism could lower #tau levels in #dementia back to the start for statins? intriguing work in any case. Cell Stem Cell VUmc Alzheimercentrum #neurotwitter

alzheimersanddementia.com/article/S1552-… this is interesting. non-surgical (esp. repeat) hospitalization more strongly associated w/ #dementia than surgical hosp; work from erkisson + al in Alzheimer's & Dementia Journals Karolinska Institutet maybe reflects frailty? or other comorbidity? #Alzheimer #neurowtiter

The preprint is out! We use diffusion models to show strong evidence of tau spreading through communicating neurons, even in normal aging. The process may then be accelerated by amyloid. biorxiv.org/cgi/content/sh…

Approximately 50% of adults over 80 with significant Alzheimer’s disease pathology show normal cognition. Arenaza-Urquijo et al. identify a brain metabolic ´resilience signature´ in cognitively stable 80-plus adults. bit.ly/2UyexUI

jamanetwork.com/journals/jama/… dietary cholesterol and egg consumption linked to increased CVD/all cause mortality 😱 heavy blow with easter just around the corner Konstantin Krychtiuk JAMA

hello twitter! preparing a talk on sex differences in #alzheimers and #dementia, any papers that I could've missed but really should include? all pointers appreciated. thank you! Women's Brain Foundation @WomenAgstAlz Rachel Buckley 🐨🇦🇺🐨 Sylvia Villeneuve

Can someone explain why manuscript metadata (title, key words, authors, perhaps even abstract) can't live in some kind of file (json, whatever) that I can submit instead of typing out 18 co authors email addresses every time? Elsevier Springer Nature Oxford Academic

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what are your plans for a 2024 tour and when will you come to Vienna ❤️ ThereWillBeFireworks