NEW content online! The path to leptomeningeal metastasis dlvr.it/T8F5Yz

Automated real-world data integration improves cancer outcome prediction | Nature #paper nature.com/articles/s4158…

Origins and impact of extrachromosomal DNA | Nature nature.com/articles/s4158…

Human DNA polymerase ε is a source of C>T mutations at CpG dinucleotides | Nature Genetics #paper nature.com/articles/s4158…

Biggest medical discoveries of the week (🧵) 1/8 In a world first, induced pluripotent stem cells restored vision in 3 patients with limbal stem-cell deficiency (LSCD) LSCD is loss of the stem cells that replenish the cornea, and can be caused by trauma, autoimmunity or

Where the next #pandemic will come from - Global expansion of wildland-urban interface intensifies human exposure to wildfire risk in the 21st century | Science Advances #paper science.org/doi/10.1126/sc…

Mechanisms driving epigenetic and transcriptional responses of microglia in a neurodegenerative lysosomal storage disorder model | bioRxiv #paper biorxiv.org/content/10.110…

Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord | bioRxiv #paper biorxiv.org/content/10.110…

Great #scientific #discoveries of the week

Adipose tissue retains an epigenetic memory of obesity after weight loss | Nature #paper nature.com/articles/s4158…

Honored to be recognized as #HighlyCited2024 - quite a validation for my early career as #clinicianScientist thank you to the funding agencies including Fritz Thyssen Stiftung @BMBF_Bund Else Kröner-Fresenius-Stiftung

Identifying spatially variable genes by projecting to morphologically relevant curves | bioRxiv #paper biorxiv.org/content/10.110…

Atlas of the plasma proteome in health and disease in 53,026 adults: Cell #paper cell.com/cell/fulltext/…

Another week another list of #research highlights by @SamuelBHume

⚡️📣After the success of our previous pathology foundation models UNI (rdcu.be/dBMgh) and CONCH (rdcu.be/dBMf6), we are now announcing TITAN (arxiv.org/abs/2411.19666), a new state-of-the-art whole slide level foundation model trained on >330k pathology slides

There were 4 new FDA approvals in November (🧵) 1. Zanidatamab, the first approved antibody that targets two epitopes in the same molecule (HER2) It got accelerated approval, for HER2-positive biliary tract cancer, based on this single-arm trial (thelancet.com/journals/lanon…)

Biggest medical discoveries of the week (🧵) 1/8 AI for drug discovery Generative AI was used to produce selective protein antagonists of the pro-inflammatory TNF receptor, TNFR1, that do not bind TNFR2 (which is anti-inflammatory) This could improve the anti-inflammatory

Math for #MachineLearning and #Artificialintelligence — FREE 479-page PDF eBook on The #Mathematics & #Statistics Foundations of #DataScience here:👉 microsoft.com/en-us/research… 👈 ———— #AI #DeepLearning #ML ———— ➕ Also see this #NeuralNetworks book: amzn.to/3EBc8Q2 ⬇️

10 Python Books for FREE on this Christmas Eve 🎄

Diet-microbiome interactions in cancer dlvr.it/TKCtwS