Oxidative activation of CaMKII provides physiological benefits critical to the initial and continued success of vertebrates but at the cost of disease, frailty, and shortened lifespan. Johns Hopkins Department of Medicine Hopkins Med News nature.com/articles/s4146…

Two popular machine-learning systems for predicting protein structures from amino acid sequences are now open-source and freely accessible. go.nature.com/36E17Oz

hopkinsmedicine.org/news/newsroom/…

Gabe Bever and I joined SuperHumanRadio to discuss our recent paper on aging, antagonistic pleiotropy, and oxidative stress. youtu.be/c2oCkspR4lc nature.com/articles/s4146… hopkinsmedicine.org/news/newsroom/…

"The 1st study ... to demonstrate less severe disease in wave four [Omicron] after adjusting for both vaccination and prior diagnosed infection." "Our data suggests that severe outcomes could be reduced by approximately 25% due to intrinsically reduced virulence of Omicron."

Question for Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM How to evaluate studies showing extension of mouse lifespan by genetic or pharmacological approaches, where the control mice show significantly shorter median lifespan than expected based on Jackson lab’s phenome database? Thanks!