The development of new chemical approaches and techniques has provided immunologists with an impressive arsenal of tools to address challenges once considered insurmountable. Check out our new review here sciencedirect.com/science/articl…

Together with the Cravatt group, we have a new manuscript out reporting the chemoproteomic discovery of covalent FOXA1 ligands that bind its DNA-binding domain, corrupt its motif preferences, and redistribute it on the genome. 1/11 biorxiv.org/content/10.110…

1/7 Our work online today, showing that targeted desialylation enhances the efficacy of bispecific T-cell engager (BiTE) for treating solid tumors #glycotime rdcu.be/dGnDG

Hiring alert! the Dao lab is looking for an enthusiastic postdoc to join us at St. Jude Research Hospital. If you are interested in conducting research at the interface of chemical biology, chromatin biochemistry & cancer biology, read more here:talent.stjude.org/careers/jobs/J…

🔊Check out our work in Science Magazine. We identify a new weak point (TCG codon) in the codon table of mammalian cells and recode it into non-canonical amino acids (ncAAs) with impressive efficiency and selectivity. This strategy, rare codon recoding (RCR), is very different!

How do combinatorial histone modifications impact gene expression? Our latest research aims to unravel this mystery. By engineering a mutant LSD1 enzyme (Y391K), we've disrupted the crosstalk between H3K4me and H3K14ac to explore its role in gene regulation. Check out our study!

Thrilled to share our MultiMap paper is now published online on Science. Science Magazine With Jim Wells, we present a multiscale photocatalytic proximity labeling platform for interactome profiling. science.org/doi/10.1126/sc…

TWeeP (This Week's Paper): Highly selective ligations of large protein complexes? No problem! In J. Am. Chem. Soc., Wallace, Jo, and DeGrado show SuFEx chemistry for site-selective ligation of pore-forming proteins stabilizing a huge, 280-kDa 18-subunit complex. pubs.acs.org/doi/abs/10.102…

We are excited to share our lab’s first research article! rdcu.be/dU5AC We have developed Transferrin Receptor Targeting Chimeras (TransTACs), a novel class of heterobispecific antibodies designed for targeted degradation of membrane proteins. nature.com/articles/s4158…

Our new PKC biosensors are finally out! Thank you everyone!

Tour-de-force application of SuFEx click chemistry in ligand optimization and glycobiology discovery led by Chao Wang from the Peng Wu lab! 🥳

Today in nature we share our back-to-back stories with Ning Zheng revealing chemical-genetic convergence between a molecular glue & E3 ligase cancer mutations. 1/6

Thank you Damon Runyon Cancer Research Foundation for your continuous support!