Now that Brad Rodu and colleagues have provided a fatal rebuttal of the inferences made in this 'gateway' study, I hope @SGottliebFDA will retweet their critique so his followers understand why it doesn't support the claims he made about it > pubpeer.com/publications/8… #science

1/3. New study by PMIScience: modern-day regulatory genotoxicity (micronucleus) assay conducted under GLP. Important to consider these results when talking about #THR with #ecigs, #snus or #heatnotburn. ncbi.nlm.nih.gov/pubmed/31294873.

2/3. Results: in vitro genotoxicity of nicotine likely driven by its lysosomotropism. However, potency and mechanistic insights indicate that it is likely of minimal physiological relevance for nicotine consumers.

3/3. Indeed, genotoxicity (micronuclei) observed at concentrations (Point of departure = 3.94 mM) several orders of magnitude above maximal human exposure (0.6 µM in plasma, 10 µM in saliva).

Dr. Moira Gilchrist Vera daCosta e Silva Tedros Adhanom Ghebreyesus Mike Bloomberg World Health Organization (WHO) Whatever people say, the scientific facts remain, and fortunately they do not abide by opinions, laws or policies: Reduced toxicants emissions lead to reduced toxicants exposure, which leads to reduced toxicity, which leads to reduced adverse health effects. #THR

An Editorial in The Lancet made false accusations about Philip Morris International’s #Unsmoke campaign. We want to set the record straight. Here are the facts: insid.pm/6011ECZFL

"These cross-sectional findings suggest that smoking effects on the lung may be at least partially reversible in smokers switching to e-cigs, findings which need to be substantiated in longitudinal studies including randomized trials." 1/2 ncbi.nlm.nih.gov/pubmed/31848205

🇺🇸FDA Authorizes Marketing of IQOS as an MRTP The agency found that an IQOS exposure modification order is appropriate to promote the public health. Exhausted but happy😃 businesswire.com/news/home/2020…

The FDA determined that issuing exposure modification orders for the IQOS Tobacco Heating System is "appropriate to promote the public health" and is "expected to benefit the health of the population as a whole''. More ➡️ spr.ly/6019GTtUx

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