Session1 of the 2nd day started with Ji Sun's talk about LRRK2 structure and there were more talks all about the structure and modulator of LRRK2. Gloria Shi, a PhD student from MRC PPU was Co-chairing the session with Patrick Lewis. Biochemical Society #BiochemEvent

Session2, Day2 Prof Dario Alessi from MRC PPU talked about the role of LRRK2 in lysosome. Elisa Greggio introduced us with BDNF and PAK6, and how they can regulate LRRK2 function. Yulan Xion talked about a fascinating pathway of LRRK2 mRNA decay. Biochemical Society #BiochemEvent

Session3, Day2. From Ciliogenesis to AMPA receptor, 21 subtypes of SN neurons - a brain storming session! Big thanks to Suzanne Pfeffer, Sabine, Anusha, and Deanna-a session with all women scientists! Biochemical Society #BiochemEvent

Round table discussion chaired by Suzanne Pfeffer and the Poster session. I am deeply grateful to Parkinson's UK for sponsoring the Early Career Member Bursary, and to the organizers for selecting my abstract for a poster presentation. Biochemical Society #BiochemEvent

Session4, Day3, Part1. Amazing talks on LRRK2 function in periphery by @MaluTansey, Nicolas Dzamko, and Rebecca. Biochemical Society #BiochemEvent

Session4, Day3, Part2. Wnt signaling and LRRK2 by Yunan Peng and proteomics study from urinary extracelluar vesicles in LRRK2 KO rats by Jean-Marc Taymans. Biochemical Society #BiochemEvent

Team Alessi at the Bienneal International LRRK2 Meeting 2024, Crete. MRC PPU Mahima Swamy Esther Sammler Biochemical Society #BiochemEvent

Session6, Day3. Great talks by Matt Farrer, Mahima Swamy, Gloria Shi, Adamantios Mamais, and Pier Giorgio Mastroberardino. Biochemical Society #BiochemEvent

A nice walking tour at Crete. Thanks to the organisers for planning this. Biochemical Society #BiochemEvent

Join us!! Postdoctoral researcher position available in #ClinicalProteomics #MND Please refer to the link below for more details and how to apply. ppu.mrc.ac.uk/careers/recrui…

Think you know how granzymes work? Think again! GzmA protects against intestinal Salmonella infection, but GzmB helps Salmonella, and perforin has no role at all. Read about this complex story of the battle between host and pathogen here tinyurl.com/2enehsx9 Tweetorial below

It takes a great deal of hard work and perseverance to create a story like this. Congratulations to Pawan, Shalini Agarwal, IlariaVolpi, and the Prof. Muqit team.

Researchers leading groundbreaking cancer and Parkinson’s research have been given almost £30 million to bolster their vital work over the next five years. 👏 We are enormously grateful to Medical Research Council – UKRI for their generous support for MRC PPU. More: buff.ly/3XbPTuA

RNA can kiss too!

Our latest research on #LRRK2 has just been published in Nature Immunology with Springer Nature where we show important negative data that this kinase important in #IBD is not expressed and not needed for Paneth cell lysozyme regulation. MRC PPU Read here: rdcu.be/dWnwq

Research led by Ramchandra Amnekar and Toby Dite has uncovered a new mechanism by which the WNK signalling pathway is activated by the NRBP1 Pseudokinase biorxiv.org/content/10.110…

Congratulations Ram. After a long wait finally it is out!

I am thrilled to announce that I have received a project grant to explore the role of lysosome biology in the pathogenesis of Parkinson's disease. Grateful for the support from Tenovus Scotland and MRC PPU!