🆕 RCSI research has shown how a new medicine could treat the common bleeding disorder, von Willebrand disease. The team RCSI School of Pharmacy and Biomolecular Sciences demonstrated how the drug helps to maintain levels of von Willebrand clotting factor in the blood. 🔗 rcsi.com/dublin/news-an… #RCSIdiscover

VWF-R1205H (Vicenza), known for causing enhanced clearance of VWF, ▶️causes conformational changes in the VWF-D’D3 domains & enhances VWF binding to clearance receptors LRP1 and SR-A1. James ODonnell ICVB RCSI RCSI David Lillicrap Jamie O' Sullivan sciencedirect.com/science/articl…

Our NEW Primer on von Willebrand disease is live today! By Omid Seidizadeh, Eikenboom, @cecile_denis, Veronica Flood, @james_paulad, Peter Lenting, Baronciani, James ODonnell, David Lillicrap & flora peyvandi #Hematology #VWD Check it out here: go.nature.com/3WyE82i

Prof. Hervig will be sorely missed by all in the IBTS. We wish him a very happy retirement!

The gene encoding von Willebrand factor is located on the short arm of chromosome 12, and a highly homologous pseudogene that does not generate functional transcripts has been mapped on chromosome 22. #VWD go.nature.com/4cSDuCA

von Willebrand factor synthesis occurs in endothelial cells and megakaryocytes as a single-chain polypeptide that, subsequently, undergoes extensive processing. #VWD go.nature.com/4cSDuCA

Dr Alain Chan Kwo Chion RCSI School of Pharmacy and Biomolecular Sciences features in the Silicon Republic list of researchers to follow 🔬 Based at ICVB RCSI his research focuses on approaches to treat the common bleeding disorder von Willebrand disease. More ➡️ siliconrepublic.com/innovation/7-e… #RCSIdiscover

Novel functions for von Willebrand factor ow.ly/rvCi50Tr8cP #thrombosisandhemostasis #vascularbiology

▶ Advanced analysis of platelet metabolism and mitochondrial function Sonia Águila, @Sonia_AguilaM, Centro Regional de Hemodonación, IMIB-Pascual Parrilla, UCAM, Murcia (Spain) ▶ How is NO metabolism regulating platelet function Paolo Gresele, University of Perugia (Italy)

👀Let’s take a peek at the story that made our #october #coverart In #vWD type vicenza, #vWF clearance is accelerated. How⁉️ 🧬 Atiq et al. showed that the VWF-R1205H mutation leads to loss of positive charge and increased binding to macrophage clearance receptors via LRP1 and

#BT200 prolongs VWF half-life by attenuating macrophage-mediated clearance and specifically the interaction of K1405-K1408 in the VWF-A1 domain with macrophage LRP1. A anovel therapeutic approach for #von Willebrand disease and #hemophilia. ashpublications.org/blood/article/…

Valuable information on the mode of action of BT200 published in Blood Advances. It blocks VWF clearance through LRP1. BT200 is a treatment being developed for non-type 3 von Willebrand disease. tinyurl.com/mss46ja3 #VWD #VWF #Willebrand

REMINDER: Our next #PBSResearch seminar series supported by Thermo Fisher is tomorrow Tues. 1st Oct. at 3pm in the Cheyne LT. We are thrilled to welcome Prof. James Luyendyk (Jim luyendyk) from MSU to see his fascinating work ‘targeting vWF to accelerate liver repair’🔬

Very excited to share our science and kick off new collaborations. Coffee is also mentioned, which is excellent.

BT200 interaction with the VWF-A1 domain in proximity to this lysine cluster significantly attenuates macrophage LRP1-mediated clearance. ow.ly/qa6A50Twvon #thrombosisandhemostasis

Montgomery Educational Symposium on Hemostasis (MESH) was a huge success thanks to the incredibly bright minds and warm hearts that gathered to honor ‘Montgomery, Milwaukee’s’ amazing career Versiti Blood Research Institute

President of Haematology Association of Ireland Paul Browne giving an overview of 25 years of the #HAI and recognition of Liam O’Connell - Ireland’s first haematologist. St James's Hospital Trinity College Dublin Trinity St James's Cancer Institute

Celebrating the great news of promotion to Professor of nursing for our colleague Deirdre O'Donnell RN, PhD, SFHEA @ulsterunisonp Congratulations Professor O’Donnell!! We are #proudofuu #ulsternurse #ulsterparamedics

Delighted to be promoted to Professor of Nursing. Thanks to everyone who has supported me and believed in me.

New RCSI research has identified a previously unrecognised subgroup of patients with the bleeding disorder von Willebrand disease. The findings challenge current diagnostic practices and highlight a need to adapt clinical guidelines. ➡️ rcsi.com/dublin/news-an… #RCSIdiscover