A baby named KJ, who was born with a rare genetic disorder – CPS1 deficiency – is healed thanks to doctors at the Children's Hospital who administered the world’s first personalized gene-editing treatment. The research team used base editing, a gene-editing method invented by HHMI

Our new paper describing the RNF114 protein as a reader of dual hydrid modification composed of ADP-ribose and ubiquitin (ADPr-Ub) we discovered a few years ago (collaboration with the lab of Gerbrand van der Heden van Noort) biorxiv.org/content/10.110…

Online Now: BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability dlvr.it/TL3D5r

What is the E3 ligase/Deubiquinating enzyme for your protein?😁👇 UbiBrowser 2.0: a proteome-wide known & predicted E3/DUB-substrate interactions database in 39 eukaryotic species ubibrowser.bio-it.cn/ubibrowser_v3/… ~4k/1900k known/predicted E3-substrate interactions ~1k/300k

Wondering what is a nucleoporin doing at repair sites? Check it out in our most recent paper in Molecular Cell! dlvr.it/TLBMbH

Hear from OCRP leaders in this video series on how the Ovarian Cancer Academy supports researchers in making ovarian cancer the focus of their scientific careers and accelerating progress in the field: youtube.com/watch?v=rC2GhP… youtube.com/watch?v=ogO4fq… youtube.com/watch?v=DwWVcP…

Green Listed v2.0: A Web Application for Streamlined Design of Custom CRISPR Screens liebertpub.com/doi/10.1089/cr… Henkel et al.

Really excited to share our new study, where we identified ZNF280A, a novel regulator of homologous recombination during DNA repair, linked to the human 22q11.2 distal deletion syndrome. A special shout out to Thomas Clarke for leading the project! nature.com/articles/s4155…

Awesome paper from Steve Jackson Lab and Johannes Walter about USP37 and TRAIP regulating the replication response to topoisomerase inhibitors. Glad to be a part of it. nature.com/articles/s4146…

Online Now: TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling dlvr.it/TLjbyj

The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells dlvr.it/TLmD25

We are hiring! Please help spread the words. Thank you! nature.com/naturecareers/…

Isoform-specific function of NSD3 in DNA replication stress confers resistance to PARP inhibitors in prostate cancer dlvr.it/TLzDpJ

📢 For all HaloTag lovers💙💚💛❤️💜🩶 we are excited to share that our work, in which we developed a new biotin-HaloTag ligand, is now published in Journal of Cell Biology! Full link here: rupress.org/jcb/article-ab…

Proud to share our new nature study: We developed the 1st NNMT inhibitor that reprograms cancer-associated fibroblasts, boosting immune response & stopping tumor growth in ovarian cancer models, especially when paired with immunotherapy. Lengyel Lab nature.com/articles/s4158…

Check out our latest work on cell cycle inhibitors, which has implications for how cancer cells could become resistant to these drugs #senescence #cellcycle #Cancer biorxiv.org/content/10.110…

Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry nature.com/articles/s4158…

Online Now: Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress dlvr.it/TMSryv

KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer dlvr.it/TMVKGH

The pearl necklace model of transcriptional silencing—developed in collaboration with Diego Castrillon’s team—explains a phenomenon observed in > 80% of human endometrial cancers. The study is now published in a peer reviewed journal. jci.org/articles/view/…