New work from soon-to-be Dr Preeti Manandhar and Marina Santiago looking at the intrinsic efficacy of Tapentadol and comparable opioid analgesics ... operation modelling, single nucleotide polymorphisms of µ receptor ... check it out ! bpspubs.onlinelibrary.wiley.com/doi/full/10.10…

#Tapentadol is a clinically relevant mu-opioid receptor agonist, but its molecular actions are not fully understood. Manandhar et al. have shown that Tapentadol has a lower intrinsic efficacy than both #oxycodone and #morphine. #Opioids #Pharmacology #PR_P buff.ly/3gnPjEW

It was great feeling like a student again, back in the lecture theatre for our Laser Safety course UNSW

Parkinson's diagnosis is difficult, relying on expensive and invasive tests, and assessment of symptoms. Researchers at @unsw @SingMolSci are developing a simple blood test to detect Parkinson's disease, with results available in hours: unsw.edu.au/medicine-healt…

I am proud of how far I’ve come and its all thanks to Dr Mark Connor and Marina Santiago for their constant encouragement and believing in me even at times when I myself had lost hope. With the weird black hat and wizard robe, I fly unto my future. PhD done, Hear Me Roar 🦁

A new paper from the lab - first paper for first author - our talented team member Noah α-Synuclein Strains and Their Relevance to Parkinson’s Disease, Multiple System Atrophy, and Dementia with Lewy Bodies mdpi.com/2411058 #mdpiijms via IJMS MDPI

Checkout this amazing review on strainotypes of alpha-synuclein in #Parkinson #MSA #DLB Congratulations Noah. So proud of you. @SingMolSci @alpha_synuclein mdpi.com/1422-0067/24/1…

Happy employees = happy employers UNSW beautiful “A Week of Winter Warmers” event. Preeti Manandhar Justin Sierecki-Gambin Group

Some light weekend reading: How should we be using biomarkers in trials of disease modification in #Parkinsons - from Nirosen Vijiaratnam & Tom Foltynie; "An ongoing systematic process of confirming clinico-biomarker validity & utility is required", Useful review! academic.oup.com/brain/advance-…

When you have French bosses, some lunches are real treats Preeti Manandhar Justin Sierecki-Gambin Group

Another piece of the Life of a Neuron exhibition! Visual artists created a real sense of movement based on our lab micrographs❤️#neuroscience #sciart

Indian cuisine today for lunch - Rajma chawal. The benefit of a multicultural team. Justin Preeti Manandhar Sierecki-Gambin Group. #teambuilding

We are a step closer than yesterday towards developing blood test to detect #Parkinson’s disease. To learn more about our work, follow our page Sierecki-Gambin Group

Great talks and poster presentations from talented scientists @ The 2023 SBMS Research Symposium from UNSW Medicine & Health

Tour of “The Illuminators” exposition @unsw #diversityfestival

We are very excited to be one of the fortunate projects awarded an ARC #DiscoveryProject grant. @SingMolSci UNSW Medicine & Health

Great collaboration of Yann and Emma from Sierecki-Gambin Group . The DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acids | The EMBO Journal embopress.org/doi/full/10.10…

Another paper from our lab Sierecki-Gambin Group - Single molecule fingerprinting reveals different growth mechanisms in seed amplification assays for different polymorphs of alpha Synuclein fibrils. biorxiv.org/content/10.110…

🥟🥟 Best team Sierecki-Gambin Group building exercise (unintentional we only wanted to eat) - make and eat 180 Nepalese momos in 1.5hrs. Thank you Preeti Manandhar for bringing all the consumables 🥟🥟