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Bioorthogonal information storage in L-DNA with a high-fidelity mirror-image Pfu DNA polymerase go.nature.com/3j1IbPF

Wow. There's a lot to take in in this preprint from Huck Group, but it should be of interest to a fair few Prebiotic Chemistry people...

Structure-activity relationships in nonenzymatic template-directed RNA synthesis (Giurgiu & Szostak) onlinelibrary.wiley.com/doi/abs/10.100…

Single nucleotide translation without ribosomes (Richert) nature.com/articles/s4155…

Prebiotic Photochemical Coproduction of Purine Ribo- and Deoxyribonucleosides (Xu & Sutherland) pubs.acs.org/doi/10.1021/ja…

A cyanosulfidic origin of the Krebs cycle (Ritson) science.org/doi/10.1126/sc…

A physicochemical orthophosphate cycle via a kinetically stable thermodynamically activated intermediate enables mild prebiotic phosphorylations (Huck) nature.com/articles/s4146…

The chemistry of branched condensed phosphates (Jessen) nature.com/articles/s4146…

Lost in Condensation: Poly-, Cyclo-, and Ultraphosphates (Jessen) pubs.acs.org/doi/abs/10.102…

Transamination between biological keto and amino acids is typically mediated by enzymes, but metal ions can do it too. To understand how, we did a mechanistic deep dive, now out in J. Am. Chem. Soc.. Congrats Robert Mayer, Harpreet & Sophia Rauscher!

Prebiotic photoredox synthesis from carbon dioxide and sulfite (Sutherland) nature.com/articles/s4155…

Concurrent Prebiotic Formation of Nucleoside-Amidophosphates and Nucleoside-Triphosphates Potentiates Transition from Abiotic to Biotic Polymerization onlinelibrary.wiley.com/doi/10.1002/an…

Acid-catalyzed RNA oligomerization from 3,5-cGMP (Braun Universität München, Sponer Akademie věd ČR, et al.) #OpenAccess through #ProjektDEAL onlinelibrary.wiley.com/doi/10.1002/ch…

The Prebiotic Kitchen: A Guide to Composing Prebiotic Soup Recipes to Test Origins of Life Hypotheses (Vincent, Colón-Santos, Cleaves, Baum, & Maurer) mdpi.com/2075-1729/11/1…

Dynamic Exchange of Substituents in a Prebiotic Organocatalyst: Initial Steps towards an Evolutionary System (Trapp) onlinelibrary.wiley.com/doi/10.1002/an…

New @emergenceoflife publication from Braun and Mast groups in collaboration with Dora Tang. Happy reading! nature.com/articles/s4155…

Prebiotic membranes and micelles do not inhibit peptide formation during dehydration (Cohen & Keller) …mistry-europe.onlinelibrary.wiley.com/doi/abs/10.100…

Delighted to share the latest paper from our lab COoL Lab, which is now online Life MDPI We thank IISER Pune SERB UGC INDIA for all the support. Great collaboration with Martin J. Van Kranendonk & Luke_Steller from Australian Centre for Astrobiology UNSW mdpi.com/1408722 (1/4)

Energy at Origins: Favorable Thermodynamics of Biosynthetic Reactions in the Last Universal Common Ancestor (LUCA) (Wimmer & Martin) frontiersin.org/articles/10.33…

From amino acid mixtures to peptides in liquid sulphur dioxide on early Earth (Trapp) nature.com/articles/s4146…