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Our paper on the mechanism of phage sensing and restriction by toxin-antitoxin-chaperone (TAC) systems is out in Cell Host & Microbe! We study two antiphage TACs: HigBAC and CmdTAC. Gemma C Atkinson Henrik Strahl Alexander Harms Medicinska fakulteten, Lunds universitet Lund University cell.com/cell-host-micr…

Excited to share my preprint from Aaron Whiteley lab showing how a bacterial NLR-related protein detects phages through the host chaperone DnaJ! This is one of the few ssRNA phage defense systems identified, and we found an interesting detection mechanism biorxiv.org/content/10.110…

Thrilled to see this one out! It's been so much fun to go over so many great papers from the last years 🙏🏼

A picture is worth 1536 plaque assays. While we used a robot, we also tried a dirt-cheap 3D-printed alternative which works wonders at 384-density. I really believe this pre-print has the potentially to be the largest impact I will make on my field. biorxiv.org/content/10.110…

Check out the latest story from the Sternberg group: phages coopted transposon-encoded nucleases (TnpB) and repurposed them for regulation of host genes! nature.com/articles/s4158… Thrilled to see this work in print, & a huge thanks to my amazing co-authors!!

Nature research paper: An anti-CRISPR that pulls apart a CRISPR–Cas complex go.nature.com/3VJPeQm

Check out our new paper at Nature rdcu.be/dMEcv We found an anti-CRISPR that pulls apart a type I-F CRISPR-Cas complex by binding to the Cas7 subunits and extracting them one at a time. Big Congrats!! to my pdf Chantel Trost who did most of the work.

Thrilled to share the final version of my postdoc project, out today in nature! We investigated the Bil system – a ubiquitin-like antiphage defense system – and discovered a new defense mechanism! More info in the thread below 👇 nature.com/articles/s4158…

Out today in nature! I am thrilled to share our work on the PARIS immune system in its final published form. Huge thanks to my mentor, Kevin Corbett Kevin Corbett, and my teammates. See the thread below in comment section for a quick summary! nature.com/articles/s4158…

nature.com/articles/s4146… Control of lysogeny and antiphage defense by a prophage-encoded kinase-phosphatase module

Latest from the lab! PICI and prophage-encoded Tai proteins protect cells by blocking phage tail assembly. Prophages counter with a mechanism allowing tail formation after induction. Defence and counter-defence genes are organised for expression. nature.com/articles/s4146…

An anti-CRISPR that (quite literally) deconstructs #CRISPR – was a pleasure spotlighting this latest discovery from the Davidson Lab in Molecular Cell, with Peter Fineran. Speculation included! authors.elsevier.com/a/1jjHE3vVUPRm…

A nice little highlight here in Nature Reviews Microbiology by Adrian Cazares 🇲🇽 and team on our work (+ from the Dechesne lab) rediscovering plasmid-dependent phages! A hundred or so are known (most isolated in the last few years!) and we've only scratched the surface 👀 nature.com/articles/s4157…

Preprint alert 🚨! I present you the second and final manuscript on the BASEL phages! 36 new deeply characterized phages from viral groups that were so far mostly terra incognita - and all infect the E. coli K12 lab strain with easy tricks. 1/12 tinyurl.com/3xdt65f5

"You can check out any time you like, but you can never leave" Hotel California for #phage on TWiV 1151 #podcast microbe.tv/twiv/twiv-1151/ MicrobeTV Karen Maxwell Pramalkumar Patel

Happy to share our work in Nature Microbiology. Gamma-Mobile-Trio systems are mobile elements rich in bacterial defensive and offensive tools. If you're interested in #Antiphage #T6SS #Vibrio #MGE then this is for you. 🧵1/15 rdcu.be/dXMwQ nature.com/articles/s4156…

Did you know that bacteria remember their past for many generations? In this new preprint from us (Alexis Villani and Senen Mendoza) and Banin lab (Esther Shmidov ), we reveal the "how?" and "why?" underlying a long-standing mystery in bacterial memory. biorxiv.org/content/10.110…

Our paper out Cell: Structure-guided discovery of viral proteins that inhibit host immunity Congrats Erez Tzvi Yirmiya, Azita Leavitt, Gil Amitai 🎗️ 🇮🇱🎗️, our collaborators @ Kranzusch lab, and coauthors A 🧵 1/10 cell.com/cell/abstract/…

Happy to share our new preprint describing prophage encoded anti-phage defense system,TERi, that targets the terminase complex of invading phages to inhibit DNA packaging. The system also encode self immunity proteins that protect the prophage. biorxiv.org/content/biorxi…