Our paper describing large-scale variation in human TCR V and J germline genes is now available at biorxiv.org/content/10.110…, a fascinating piece of work by incredible Martin Corcoran and a great team. Enjoy!

A study by @benjmurrell et al shows that #SARSCoV2 #Omicron sublineage BA.2.75.2 largely evades neutralizing antibodies in the blood and is resistant to several monoclonal antibody antiviral treatments. Now published in The Lancet Infectious Diseases. news.ki.se/new-omicron-su…

🤯

Ridiculous.

We are a fun bunch of antibody geeks ♥️ Gunilla Karlsson Hedestam group at Karolinska Institute, Sweden 😊 Karlsson Hedestam Lab

”Med rådande migrationshantering går Sverige miste om kompetens inom forskning” - läs hela min debattartikel om hur migrationspolitiken och lagstiftningen drabbar forskarsamhället i Forskning & Framsteg fof.se/artikel/absurd…

Outstanding work by talented doctoral student Pradeepa Pushparaj with great support from Andrea Nicoletto and several others in the group + dedicated collaborators. IgDiscover helps us understand why we respond differently to infections.

"When I first came here, I'm a bit ashamed to admit this, but I was trying to hide the fact that I came from Lebanon." 2021 medicine laureate Ardem Patapoutian on the importance of inclusion and learning to love his immigrant background. #NobelPrize

I wanted to summarize what is known about the new XBB.1.5 variant of SARS-CoV-2, which is starting to generate a lot of interest. (There are no new scientific results in this thread, it simply aggregates previously reported results for those not following topic closely.)

From Karlsson Hedestam Lab lab - Personalized immunoglobulin genotyping coupled with monoclonal antibody engineering identifies germline-encoded polymorphisms that influence our anti-viral B cell response. @MTC_KI #MTCPubs doi.org/10.1016/j.immu…

“Understanding antibody germline gene variation is important as it can help explain why we differ in our abilities to control infections or respond to vaccination” full interview here news.ki.se/new-publicatio…

Our paper now out in Immunity authors.elsevier.com/sd/article/S10… doubles the number of known expressed TCR alleles, providing new possibilities in T cell immunology research. Thank you Vetenskapsrådet, European Research Council (ERC) and Karolinska Institutet for supporting our team.

Antibody gene features associated with binding and functional activity in vaccine-derived human mAbs targeting malaria parasites biorxiv.org/cgi/content/sh… #biorxiv_immuno

Sharing some new experimental data on BA.2.86: 1) BA.2.86 is antigenically distinct compared to XBB.1.5. 2) BA.2.86 can significantly escape XBB-infection/vaccination induced antibodies. 3) However, the infectivity of BA.2.86 may be much lower than XBB.1.5 and EG.5. (1/n)

Real-time data update: we've got our first BA.2.86 (see red arrow) neutralization results. Short 🧵with much credit to Daniel Sheward and the rest of the team.

Very well deserved! :)

Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem dlvr.it/Sz4Cs3

By reintroducing somatic hypermutations into a germline-reverted mAb, we delineate the role of affinity maturation in the development of cross-neutralization in a public class of antibodies. As always, antibodies are fascinating. Thanks to Karlsson Hedestam Lab and everyone involved 🤍

It's an absolute scandal and tragedy that India is forced to spend $250m/year to provide access to the latest science to its people. A complete and total failure of global science leadership and of science writ large.