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Remember your high school biology textbook saying bacteria don't have histones? Turns out, researchers have proven otherwise! Check out LMS researchers' study to learn more!@tobias_warnecke Antoine Hocher Nature Microbiology #HistonesInBacteria #Microbiology ow.ly/zFuY50PSwGX

RoseTTAFold updated to be All-Atom... biological assemblies containing proteins, nucleic acids, small molecules, metals, and covalent modifications ... and diffusion🤯biorxiv.org/content/10.110…

Jason de la Cruz and I reviewed how growth in #cryoEM technology across the three main TEM modalities is helping cryoEM mature as a tool & enabling new research paths. Our open access article - Scaling up cryoEM for biology and chemistry… is now online: doi.org/10.1016/j.str.…

Nice update, so now I don't need to move my particles around between CryoSPARC and Relion anymore 😌

Sorry but I couldn’t restrain myself from making this 😅 (just for laughs, no offense intended) #cryoET

Doing my bit.

The HUSH complex guards vertebrate genomes from retroelements. Our new structural/biochemical study on MPP8 reveals the interaction interface with TASOR required for HUSH assembly & suggests links between HUSH & SUMO doi.org/10.1101/2023.1… Danya Prigozhin Medicine at Cambridge @MRC_LMB

1/6: #CryoEM Exhausted with fighting the air-water interface (AWI) problem during sample grid plunge freezing? We may have an easy solution for you! Read our latest preprint on how we use LEA proteins as AWI sample protectants for challenging samples: biorxiv.org/content/10.110…

Over 4 years in the making, I am excited to share our pre-print on the “In-cell structure and snapshots of copia retrotransposons in intact tissue by cryo-electron tomography”. We used cryo-ET to resolve the copia capsid structure to subnanometer resolution inside cells. A 🧵

Excellent review nature on using the interplay between cryoEM and cryo electron tomography to study macromolecular complexes in situ! From Julia Mahamid EMBL and The Nogales Lab nature.com/articles/s4158…

We're thrilled to announce our new preprint on the structure of the human alternative clamp loader, CTF18, bound to PCNA. A big shoutout to our star PhD student Giusy Briola for spearheading this work! biorxiv.org/content/10.110… #DNAReplication

🧬 Thrilled to share our latest research on Retrons—a new chapter in this fascinating field! 🌟In this Molecular Cell paper, we reveal how Retron-Eco1 defends against phages. bit.ly/3WOlbsY Check the 🧵below! (1/20)

One exciting application: given a cryo-EM density map, ADP-3D can refine an incomplete or inaccurate atomic model (e.g. given by Modelangelo)! 4/

We are happy to share our latest work on RNA polymerase I! We continued our #CryoEM study of its stalling mechanism, this time at abasic lesions, and uncovered interesting Pol I configurations. Read more at bioRxiv: biorxiv.org/content/10.110…

We're hiring! Are you looking for a PhD position in structural biology? We offer a fully-funded 4 year contract to study basic processes connected to transcription. If you're interested in joining us in sunny Madrid, get in touch with us!

Our in-situ structural analysis of the Ebola virus nucleocapsid is now published in Cell! Using cryo-FIB-ET, we revealed a 9Å structure, identifying novel layers and conserved interfaces that may serve as antiviral targets. #Ebola #Virology #StructuralBiology

Vertebrate retrotransposons are the future of gene therapy. But how do they insert their genes? 🔥🔥 Thrilled to present part 2 of my postdoctoral work with The Nogales Lab Collins Lab UC Berkeley MCB where we investigate this using #CryoEM and transgene insertion in 🧪 and cells!

Now most folks cant tell the difference between an Xray diffraction pattern and #MicroED 😁 Behold 0.9Å 😍

Our latest work shows how energy filtering, PFIB, and direct electron detection unlock sub-atomic resolution for #MicroED! 🎯 Great work from Max Clabbers and JohanHattne back when I was with Tamir Gonen at UCLA Biological Chemistry. Excited to bring this capability to UBuffalo!

Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ Jan Philipp Kreysing, Johannes Betz,Turoňová lab, Marina Lusic, Hummer lab, Beck Laboratory, Max Planck Institute of Biophysics 🔗 Preprint here: doi.org/10.1101/2025.0…