Congratulations to Bell and Yi on back to back Cancer Discovery papers. Go Sheila Stewart and Siteman Cancer Center aacrjournals.org/cancerdiscover…

Now online in Cancer Discovery: back-to-back papers from the labs of Sheila Stewart and David DeNardo WUSM on immunosuppression by senescent CAFs in breast and pancreatic cancers doi.org/10.1158/2159-8… doi.org/10.1158/2159-8… Jennifer Jiayu Ye Jad Belle #DevashishSen Test Account Siteman Cancer Center

Extremely excited and honored to have been able to collaborate with the@DeNardoLabWUSMon the impact of senCAFs in #pancreaticcancer Deeply exciting work! Check it out: aacrjournals.org/cancerdiscover…

Motivation Monday! Check out these brilliant studies from David DeNardo WUSM Sheila Stewart hot off the press focused on tissue-specific, immune-modulatory fxns of senescent CAFs! 🤩

During her talk, Dr. Edna Cukierman, Ph.D. is showing that pulsed low-dose-rate radiation (PLDR) reduces the tumor-promoting responses induced by chemoradiation in #PancreaticCancer-associated fibroblasts. Read more in bioRxiv: biorxiv.org/content/10.110… #SMC3B

During her presentation, Sheila Stewart is showing that senescent cancer-associated fibroblasts suppress Natural Killer cell activity and promote #BreastCancer progression in preclinical models. Read more in a recent Cancer Discovery study: aacrjournals.org/cancerdiscover… #SMC3B #BCSM

Using preclinical models in an National Cancer Institute funded study, Marina Broz, Jlenia Guarnerio, et al. showed that metabolic targeting of cancer-associated fibroblasts (#CAFs) overcomes T-cell exclusion and treatment resistance in soft-tissue #sarcomas Nature Communications nature.com/articles/s4146….

Congrats to Shola Karimu 👩🏿‍🔬 🇹🇬🇳🇬 for receiving the Robert Mozia Graduate Service Award! ABSOLUTELY deserved! We are so fortunate to have Shola and her joyous energy for science and for life in our lab

Building a new medical device from scratch: A The Minnesota Star Tribune story shares how a team of #UMN student inventors & a UMN Biomedical Eng faculty member answered a patient’s call for help. ➡️Story: bit.ly/4bmhsH8 College of Sci & Eng U of M Research University of Minnesota Law School UMN Medical School startribune.com/no-funding-no-…

I can’t say enough good things about this meeting! It all started as a conversation on Twitter a year ago (maybe less?) Turned quickly and efficiently into a reality by Kay and her colleagues UChicagoCancerCenter . Great venue & stellar colleagues! Absolutely amazing!

I said it many times, but this time it was Dr. Weinberg et al "The major challenge of current metastasis research is to understand how rare disseminated tumour cells (DTCs) succeed in metastatic colonization..." Nice highlights CDTMI_Einstein science. nature.com/articles/s4155…

Three scientist mothers call for a change in how conference childcare costs are reimbursed, drawing on their personal experiences go.nature.com/3KfWZIB

If you're interested in anti-tumor immunity and metabolism... Arg:Orn ⚖️ TAM/CD8 Article: nature.com/articles/s4301… News and Views: nature.com/articles/s4301…

Dr. Kevin Eliceiri, Paolo Provenzano, et al. at the University of Minnesota #CCBIR Center for Multiparametric Imaging of Tumor Immune Microenvironments are advancing live-cell and tissue #imaging platforms to characterize barriers that limit antitumor immunity & #immunotherapy. cancer.gov/about-nci/orga…

David Lyden is giving the Paget-Ewing award lecture! #MRS24 Metastasis Research Society

I’m honored and excited to lead Metastasis Research Society for the next two years along with Pres-Elect Neta Erez- ErezLab🎗️ ! Thank you eriksahailab for a fantastic conference and eager to host you all in 2 years in #beautahful Utah near Huntsman Cancer Institute !!

Excited to attend the cancer prevention research conference organized by National Cancer Institute American Cancer Society and Science and Innovation at Cancer Research UK to present at a panel on early dissemination as a new space to think about prevention along with Suzanne Ponik and Hege Russnes !

Very happy to share this new work on LAG3 and PD1. Has been a long road to (begin to) sort out how LAG3 functions in CD8 T cell exhaustion. Great work by Shin Ngiow and super collaboration (and 2 other great papers) with Vignali Lab and Dario Vignali cell.com/cell/abstract/…

Astonishing breakthrough in #organoid engineering, as reported in nature by T Recaldin,M Harter,L Steinacher,B Gjeta, and colleagues: intestinal epithelial organoids incorporating tissue-resident immune cells. Institute of Human Biology Roche go.roche.com/4a5t1

The company ran a 240 patient (!) randomized phase 2 trial of Simtuzumab in #PancreaticCancer that showed no therapeutic benefit. academic.oup.com/oncolo/article… As an angiogenesis inhibitor (versus the stated inhibition of LOXL2 catalytic activity) this was essentially a rerun of Gem