今天愚人节，我翻译了几个我很喜欢的“愚人”智力趣题，题目均来自 PapiCon

4Pi-SMS and pan-ExM reveal, in a close collaboration with the Rothman lab, a surprising tetraplex organization and self-assembly of rim golgins, which we believe can explain stack formation of the Golgi apparatus: biorxiv.org/content/10.110…

Cell membranes sustain phospholipid imbalance via cholesterol asymmetry: Cell cell.com/cell/fulltext/…

MINFLUX works well in theory, but system and sample imperfections can lead to suboptimal resolution. To address this, Jonas Ries and I developed SimuFLUX: biorxiv.org/content/10.110…, a realistic simulator to optimize MINFLUX experiments before samples go on the microscope.

Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ Jan Philipp Kreysing, Johannes Betz,Turoňová lab, Marina Lusic, Hummer lab, Beck Laboratory, Max Planck Institute of Biophysics 🔗 Preprint here: doi.org/10.1101/2025.0…

There are so many weird Biology quirks that I somehow missed before and am only just finding now... Apparently translation can and *does* initiate from EVERY codon With the caveat that any codon other than the canonical AUG / GUG / UUG options induce transcription at such

Live-cell quantification reveals viscoelastic regulation of synapsin condensates by α-synuclein | Science Advances science.org/doi/10.1126/sc…

A hollow TFG condensate spatially compartmentalizes the early secretory pathway nature.com/articles/s4146…

Majority of data never get the opportunity to be published. This is F-actin clearly organized in two modes, clusters or meshes, possibly mediated by formins and Arp2/3.

Maxwell's demon

A postcard from MBL shop that accidentally features a Golgi stack 😁

We introduce a new tool to study F-actin remodeling, ADPact, a peptide sensor of ADP-actin. Unlike Lifeact and Phalloidin, which bind both ATP- and ADP-actin, ADPact only detects ADP-actin. It neither overlaps with cofilin nor affects treadmilling 🙌🤗. pnas.org/doi/10.1073/pn…

🚨 2 × PhD positions EPFL EPFL Life Sciences! Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne 🇨🇭. Start Jan 2026. Send CV + motivation + 2 refs → [email protected] #PhD #Hiring #microscopy #SpatialOmics #DNAPAINT #FLASHPAINT

Pan-ASLM: a high-resolution and large field-of-view light sheet microscope for Expansion Microscopy from Bewersdorf Lab biorxiv.org/content/10.110… Given that they built an ASLM, I have no more excuses left for not building a 4Pi microscope...

youtu.be/OhCVBx_ZD9U?si…

Rubisco is (arguably) the most abundant protein on Earth. (LPP surely comes close, right?) It’s an enzyme that fixes CO₂ into sugars during photosynthesis. Unfortunately, as most people learn in school, Rubisco is inefficient. Sometimes it confuses O₂ for CO₂ and wastes

好问题。我回答一下：以色列在加沙的做法涉嫌战争罪行，比如摧毁水井，袭击平民甚至医院造成平民死亡，强制大量平民迁移。哈马斯首先把自己藏身于平民和医院等平民设施之中，从以色列的角度来看，要消灭哈马斯而同时不伤害平民是非常困难的事情……