Over the moon about my postdoc work ⁦Science Magazine⁩ ! Ever wonder about how mammalian cells selectively degrade unwanted nuclear proteins without involving ubiquitination? Check out our paper on a non-canonical protein degradation mechanism! science.org/doi/10.1126/sc…

Very happy to have my recent work on "Time-resolved cryo-EM of G protein activation by a GPCR" out in Nature today! #cryoEM #GPCR nature #LabSkiniotis nature.com/articles/s4158…

Today in @Science_Magazine we report the laboratory evolution of compact degrons that enable targeted protein degradation triggered by an otherwise-inert small molecule, a multidisciplinary study that integrates organic chemistry, molecular glues, protein evolution, genome

Delivering and expressing a gene in cells is usually a messy (heterogeneous) process. The messiness interferes with research and applications such as gene therapy. In two new papers, we introduce a toolbox of synthetic miRNA-based control circuits that enable more precise, gene

.Tino Pleiner, Hazu, Pinton, @GPTomaleri Rebecca Voorhees et al. identify a selectivity filter in the ER membrane protein complex and show that it limits protein misinsertion at the ER. hubs.la/Q02qbfZF0 Part of our #StructuralBiology collection: hubs.la/Q02qb9Fr0

It cannot be done, they said.. It's too flexible, they said.. 😁 biorxiv.org/content/10.110… #NPC #teamtomo #integrativemodeling by Digvijay Singh Neelesh Soni Josh Hutchings Ignacia Echeverria et al. Great collaboration w/ Qiang Guo, Brian Chait, Javi Fernandez-Mtnz, Rout Lab Andrej Sali lab

A nanobody toolkit for tracking or blocking nuclear pore complex (NPC) biogenesis identifies a checkpoint linking assembly of the NPC scaffold to formation of the Np98-dominated permeability barrier Dirk Görlich and coworkers NPC-aficionado MPI for Multidisciplinary Sciences embopress.org/doi/full/10.10…

A checkpoint function for Nup98 in nuclear pore formation, elucidated with nanobodies. Congratulations to the entire team MPI for Multidisciplinary Sciences Philip Gunkel Tino Pleiner !

We're hiring! Looking for a Life Sciences Technician II to help us acquire RNA structural data on 1 billion diverse molecules: careersearch.stanford.edu/jobs/life-scie…

Two exciting postdoc positions in my lab for a microbiologist and cell biologist to study the structure-function of ATP-dependent AAA machines! Ideal for candidates seeking an academic career. bit.ly/3JWkW7z For more information, visit: sites.wustl.edu/ghanbarpour/

Come join us at Stanford University! We are recruiting those with background in infectious disease modeling and interest improving public health!

The article is online, but the research continues. Looking forward to more exploration of protein lipid interaction in the future! nature.com/articles/s4158…

I'm thrilled to announce that the Blythe Lab will open in the Department of Genetics, Cell Biology and Development at the University of Minnesota, Twin Cities in early 2025! (1/2)

Thrilled to share our preprint on the structure of a nautilus-like assembly of membrane proteins, HflK/C, that regulate the FtsH AAA protease activity, a key component of bacterial inner membrane protein degradation machinery. (1/n) bit.ly/4dotfpJ

I am excited to join Caltech Chemistry & Chemical Engineering Caltech as an Assistant Professor this November! The Fianu Lab will be a welcoming space for anyone interested in gene activity and genome stability. bit.ly/47gH9I7 We are looking for team members at all levels—please reach out!

We believe we need better tech to measure what cells are doing and to precisely control their behavior to crack the many mysteries of biology. These mysteries keep us curious, inspired, and excited. We're recruiting at all levels - reach out if you're interested in joining us!

Very excited to present the structural and mechanistic basis for stress response silencing by the monster E3 ligase SIFI. biorxiv.org/content/10.110…

Happy holidays from the Tino Pleiner. Feeling so lucky to get work with this incredible team StanfordMCP Come join us as a postdoc to work with #membrane proteins and rewire cellular processes with #nanobodies. Apply here: bit.ly/_Postdocs ... please share 🔃

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology biorxiv.org/content/10.110…