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Wopwop! Our story on Cx32 is out in Science Advances 🎉🥳 Thanks to Chao Qi , Dina Schuster and Anand and members of Bortolozzi group for a great collaborative work!

The link to the story can be found here 🔬🧫

The paper by Korkhov Lab, joint with Picotti Lab and Mario Bortolozzi group (Università di Padova), out in Science Advances, describes the cryo-EM structures of Cx32 channels and reveals a molecular defect in hemichannels of CMT1X-associated Cx32 mutants. More: biol.ethz.ch/en/news-and-ev…

Our paper on the structural and functional studies on AC8 is on bioarxiv. Great effort by the team! It is great to see implementation of complimentary techniques such as LiP-MS that add to Cryo-EM in order to probe structural and functional questions biorxiv.org/content/10.110…

The #CryoEM structure of the connexin-43 gap junction channel in a putative closed state helps researchers develop a mechanistic model for connexin activation. elifesciences.org/articles/87616…

"Please make no mistake. Climate change is the biggest threat to global security that modern humans have ever faced." Sir David Attenborough. No time to wait. #ActOnClimate #climate #energy #wildfires

nature.com/articles/s4158… My first paper as a postdoc in the lab David Drew is out Check-out the.first structure of a unique transporter which is regulated by a voltage sensing domain. Great team work!!

A bit of an update! On Thursday I successfully defended my PhD. 🥳 I am extremely grateful to all who helped me on the way and made my PhD journey in the Korkhov Lab an amazing experience. 🎉🎊

Amazing seminar on 7TM receptors today at PSI Paul Scherrer Institut by Arun K. Shukla !

Our study, led by Xinyue Ding in collaboration with Gervasio's Research Group (Protein Dynamics), exploring the molecular mechanisms of Cx36 gap junction channel inhibition by antimalarial drugs is now online👇 biorxiv.org/content/10.110…

I am very happy our study on Connexin interaction with drugs and their influence on gap junction channel permeability is out on biorxiv. 🥳 many thanks to Yufei Han , Korkhov Lab and everyone who helped with the project ✨

Another wonderful study from our colleagues Pia Lavriha & Yufei Han who further characterised the interactions of 2-APB and #antimalarial drugs with two other isoforms #connexin Cx32 & Cx43 #channels using cryo-EM and cellular assays.

Last Thursday we went to test how well our lab skills translate to other activities. ✨ We tested our problem solving skills in boda borg and made cocktails, which is almost like preparing buffers (but a bit tastier 🤫). Here are some impressions from our group activity!

We (Korkhov Lab) wrote a review on membrane adenylyl cyclases, what we know about their structure & structural aspects of their regulation. They are fascinating proteins, with interesting differences between the different isoforms. Read more here ⬇️ doi.org/10.1016/j.tibs…

A beautiful summary of our recent findings from the Korkhov Lab on the structure and function of membrane bound adenylyl cylases is out. A very cool class of proteins often over shadowed by GPCRs (also cool). Great colleague=great science. Good job team! sciencedirect.com/science/articl…

guys check this out!

Our study led by Xinyue Ding, joint with Simone Aureli, Gervasio's Research Group (Protein Dynamics), and Picotti Lab, describing the structural basis of Cx36 gap junction channel inhibition by small molecule drugs, is out in Cell Discovery 👇 nature.com/articles/s4142…

Our joint study led by Basavraj khanppnavar and Oneda Leka, on the interactions between botulinum neurotoxin BoNT/A1 and its receptor SV2B, is now out in Nature Communications. This was a great collaboration with the group of Richard Kammerer (PSI Paul Scherrer Institut)! rdcu.be/d9rOL

Our investigation of lipid dependence of Cx32 gap junction channel conformations is now online on bioRxiv. Great work by Pia Lavriha, Carina Fluri and Jorge Hernández González! biorxiv.org/content/10.110…

Come work with us at the Nucleus Sarafan ChEM-H! Happy to help you with proteome analyses, identifying your drug targets, understanding drug mechanisms, and much more 🔎🕵🏻