A beautiful metastasis story and surely an instant classic from Ralph DeBerardinis' lab in nature today. Congrats DeBerardinis Lab, Divya Bezwada, and the rest of the team!

Congrats to postdoc Nikita in the lab for winning the Hopper-Belmont Inspiration Award!!! Grateful for the Hopper-Belmont Foundation Foundation for supporting our trainees!

Thrilled to be one of the recipients for this year’s Hopper-Belmont Foundation award. Thankful for the recognition and absolutely couldn’t do it without the support of PitarresiPhD!

Epigenetic dysregulation is widespread in cancer. Using a new in vivo method, we generated a phenotypic roadmap of 250 epigenetic regulators in lung tumorigenesis in vivo. Most critical epigenetic tumor suppressors including one I hadn’t heard of before. biorxiv.org/content/10.110…

Join us! My lab UMass Chan Medical School is seeking postdocs and research associates who are passionate about how changes in metabolism and epigenetics contribute to cancer development and immune system evasion. DM me for a chat and apply at ummsjobs.com/job/10593/ (postdoc position)

18 years ago, I came to the US to pursue my dream of becoming a scientist. Last week marked a major milestone in this journey, as I accepted an Assistant Professor position at The University of Chicago, where I am thrilled to start my own research group in January 2025! (1/5)

Congrats to the Chandwani lab (Caitlin McIntyre, Adrien Grimont et al) for this beautiful paper looking at how different Kras mutations in PDAC patients alter clinical outcomes. In the era of targeted mutant Kras inhibitors, this has huge implications! cell.com/cancer-cell/fu…

With more doom and gloom coming from the NCI, it’s time to start de-coupling promotions from getting an R01. Look at your colleagues and think about where they’d be if their promotions were inextricably tied to a lottery. We can’t lose our young talent to our intransigence.

Final call to submit an abstract for short &lightning talks consideration and for travel awards! Join this exciting meeting

Innate immune activators packaged in lipid nanoparticles, and paired with two senescence-inducing chemotherapy agents, controlled tumor growth and extended survival in a mouse model of pancreatic ductal adenocarcinoma. Science Translational Medicine scim.ag/8eZ

Paper alert 🤩 stoked about publishing our story on transcriptional heterogeneity of breast cancer, profiling primary tumors and their matched metastases at single-cell resolution. out today in Journal of Clinical Investigation jci.org/articles/view/…. check out the 🧵of the pre-print 👇 1/n

I’m delighted to share our lab’s latest study now published Nature Genetics👉 tinyurl.com/2p97xpj8. Led by the fantastic duo Carina Shiau #JingyiCao, and a big collaborative effort with Martin Hemberg David Ting NanoString and others. 🧵

An autoinflammatory syndrome-associated STING mutation supports formation of germinal centers containing immunocompetent cells in the lungs of irradiated mice following BMT- insight.jci.org/articles/view/… Study from@ImmunoKevin and colleagues Kristy Chiang Kate Fitzgerald UMass Chan Program in Innate Immunity

Check out this #newpublication and beautiful images from the Kate Fitzgerald and #AnnRothstein labs in JCI insight! Department of Medicine UMass Chan Medical School

Hello #thermogenesis and #adipose folks, Ucp1 lovers and non-canonical lovers: Our recently generated Ucp1 and Ckb conditional mice will soon be available at The Jackson Laboratory: jax.org/strain/039540 jax.org/strain/039539

In a study funded by our division, Meng-Ju Wu et al. revealed a new mechanism for viral mimicry in triggering an immune response underlying the antitumor activity of mutant isocitrate dehydrogenase 1 (IDH1) inhibitors Science Magazine science.org/doi/10.1126/sc….

According to a Science Magazine Perspective about the study by PitarresiPhD & Dr. Katherine Fitzgerald, “These findings provide insight into the tumor cell–intrinsic #epigenetic mechanisms that drive immune evasion in mutant IDH1 tumors.” science.org/doi/10.1126/sc…

Happy to welcome the newest member of the Ruscetti lab, Hadiya Giwa, to the team! Hadiya recently graduated from Tufts University and started last week as a research associate in the lab. We are all excited to have you on board!