Excited to share our latest findings on how the phosphoinositide PI4P pool at the trans-Golgi network (TGN) is regulated through a SYS1-ARFRP1-ARL5-ARMH3-PI4KB pathway, in which ARMH3 (also known as C10orf76) acts as an ARL5 effector to activate PI4KB. rdcu.be/d1dZ2

This was such a fantastic day, thanks a million all. Look forward to developing the ideas next year. UKAN (UK Ageing Network)

Check out this bombshell publication by Michael Fischbach and coworkers Sarafan ChEM-H Stanford Engineering Stanford Medicine, imagine a cancer immune therapy/vaccine where treatment begins and ends with a painless topical skin treatment! 🤯

I am beginning to think that Kemi is a Reform plant whose mission is to destroy the final, dying embers of the Conservative Party.

Kemi Badenoch has revealed she rarely has time for lunch, and would rather a steak over a sandwich. She likes her steaks like her victories at PMQs - very rare

Summer studentship grant - ageing - please share

Molecular mechanism of ATP6V0A2-CDG explained: mutation in trans Golgi V-ATPase subunit V0a2 causes an increase of pH from 5.80 to 6.52, enhanced fucosylation+glycosaminoglycan modification, reduced levels of glycanated decorin and sialylation tinyurl.com/56w5dec7 #glycotime

Congratulations to the winners of the best talk prizes at the recent UK Membrane Trafficking meeting #UKMT. Alex van Vliet from Sean Munro's lab MRC-LMB Cell Biology won the postdoc prize. Katy Yalci from Bernadette Carroll’s lab Bristol Biochemistry was the winner of the PhD prize.

Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites nature.com/articles/s4146…

Ana Maria Cuervo MD PhD at Albert Einstein College of Medicine - Official speaks about Selective Autophagy: Extending health-span one protein at a time at the 228th Interurban Clinical Club meeting at Weill Cornell Medicine #ICC228

Editing 14 genes is no small feat, but I am not seeing enough evidence that "it is a dire wolf". Our community needs to communicate better to the public, now mor than ever, and imo that includes not exaggerating what we can deliver.

It's your thesis. Not the university's. Not your supervisor's. Yours. So you need to take control. Stop waiting.

Kangfu Peng, Hong Zhang et al. show that scramblase-attenuated #Celegans ATG-9 mutants rescue the #autophagy defect and lysosome damage caused by nondegradative autolysosomes. This uncovers the role of ATG-9 in regulating #lysosome function & integrity. hubs.la/Q03gCL5D0

Who did this?

We have an exciting 18 month postdoc position available in our new lab in Liverpool. If you have experience in primary cultures and are interested in Endosomal Biology and Neurodegeneration do take a look. Please repost and share. jobs.ac.uk/job/DMZ553/pos…

NEW paper 🚨 We updated the mouse data in DrugAge to reveal sex-related differences in lifespan and weight effects. We found that, mostly in males, drug-induced life extension in mice correlates with weight loss. Amazing effort by aleksey ! nature.com/articles/s4151…

I'm prototyping a little tool for interactively visualizing the near-nearest neighbor network in single-cell RNA-seq. Clicking a cell triggers a wave, revealing its nearest neighbors, then their neighbors, and so forth. Data: 10k PBMCs from a Healthy Donor (v3), 10x Genomics

Online Now: YTHDF1 differentiates the contributing roles of mTORC1 in aging dlvr.it/TL2BJm

I wrote a blog post about the new mouse longevity paper! Check next tweet for more :)

The micropipette—that ubiquitous tool found in laboratories around the world—was invented by a 32-year-old German postdoc in 1957 after a particularly productive two-day tantrum. That first device, made by Heinrich Schnitger, had “all the essential features of the modern