🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

🦠Pathogenic bacterium Pseudomonas aeruginosa breaches lung defenses by targeting mucus producing goblet cells! Intracellular P. aeruginosa may evade immune system and antibiotic treatment, thereby driving chronic infections NCCR AntiResist Institute of Human Biology doi.org/10.1038/s41564…

Go team 👏🏻

Phil Stewart passed this iconic TEM image of a P aeruginosa biofilm on to me. There is so much detail! Are those filamentous phages I see?

We're happy to present our latest preprint, where we used cryoET to study tick-borne flavivirus replication in human cells and mouse brains! #cryoEM #virology biorxiv.org/content/10.110…

Aaaaand…..that’s a wrap on #Vibrio24! Excellent meeting:fantastic talks, beautiful location, great food, good friends. Thanks to all the hard work of Salvador Almagro-Moreno and thanks to everyone for making it a success. See you in Berlin #vibrio26 UTSA Dept. of Molecular Microbiology & Immunology ASM College of Sciences

Great place to work!

Beautiful work by Ian Yen from @PLynneHowell lab and Greg Whitfield from Brun Lab in collaboration with @RubinsteinJohn revealing how the #T4cP motor works. This system has two platform proteins and only a single extension/retraction ATPase. biorxiv.org/content/10.110…

Very excited to share this collaborative work on the structure of the Caulobacter bifunctional Tad pili motor. Great work by Ian Yen and Greg Whitfield!

Here is a video that summaries the key findings! Once again, special thanks to my wonderful mentor Jun Liu Lab at Yale School of Medicine YaleMicroPath. Lots more discoveries to come at McGill Medicine and Health Sciences Anatomy&CellBiology CRBS McGill !

Our new review on regulation of #T4P type IV pilus assembly #buildingpermits, by PhD candidate Nathan Roberge, is now available for you to enjoy with your morning coffee! 😀 McMaster IIDR McMaster Biochemistry & Biomedical Sciences Global Nexus McMaster Health Sciences journals.asm.org/doi/epub/10.11…

Researchers led by Phil Shuaiqi Guo, Jun Liu Lab, Lori L. Burrows report the structure of the Pseudomonas aeruginosa T4P suggesting the localization and role of its tip adhesin, PilY1. nature.com/articles/s4146…

Now out in NSMB for those who missed our biorxiv back in 2023.. rdcu.be/dZSPQ

Excited to share our new book chapter! We summarize recent advances in the structures and mechanisms of non-fimbrial adhesins in biofilm formation, with perspectives on upcoming discoveries in this field. #BiofilmResearch #Adhesins link.springer.com/chapter/10.100…

Out today in Nature: "The Human Cell Atlas"! In my commentary, I compare the cell atlas to early naturalists exploring South America. Researchers mining this cell atlas can now make big discoveries, just as the next naturalists then discovered evolution. nature.com/articles/d4158…

🚨It’s been a long time coming, but… using my first B. burgdorferi strain as a grad student — 11 years ago — now Nature Communications with NICHD News Adams Lab post-bacs, we corrected a gene annotation mistake and discovered a conserved flagellar assembly factor! nature.com/articles/s4146…

Just published a new paper with our collaborator here at Dartmouth - Mukul Sharma. This project leverages disciplines from micro to earth sciences to oceanography to explore a new mechanism of carbon sequestration. nature.com/articles/s4159…

MotE-like proteins, including FlgY in Campylobacterota and FlbB in Spirochaetota, form characteristic ring structures across bacterial phyla. journals.plos.org/plospathogens/… biorxiv.org/content/10.110… pnas.org/doi/10.1073/pn…

More awesome cryo-ET from the Liu lab unravelling flagella motor architecture..

Excited to share our new publication with Vahidi Lab@UofGuelph 🇨🇦! We reveal how human mitochondrial ClpP is allosterically activated—even by inhibitors—unlocking new strategies to target ClpP in AML. pnas.org/doi/10.1073/pn…