All opioids act directly on blood and tissue cells to release histamine, which may produce flushing, tachycardia, hypotension, pruritus, and bronchospasm. Histamine release is greatest with large doses of morphine, while fentanyl, hydromorphone and remifentanil release little

Cirrhosis Pharmacotherapy ✨ Chart PDF and pharmacotherapy review available in your Pyrls drug information website and mobile app!

❤️‍🩹 Heart failure Management Pyrls

Upper Limb Nerve Pathology #nerve #upperlimb #neuropathy neurology.org/doi/10.1212/NE…

Respiratory Acidosis VS Respiratory Alkalosis ✔️

🩸 Iron Interactions

🩸 Anemia correction with SGLT2 inhibitor 🤷‍♀️ It’s not just due to hemoconcentration/diuretic effect of SGLT2i ✅Its also due to ⤴️EPO production ✅Benefecial in CKD- Can ⬇️ Erthropoitin dosing 👎Caution in pts with high baseline Hb level (ADPKD) academic.oup.com/ndt/advance-ar…

🧪Liver function tests abnormalities

Really great presentation this week from Niamh Hickey our UCC Pharmacy School APPEL intern on Parkinson's Disease including a very interesting #gerionc case study!

It takes >3-4 weeks of steroids (@ any dose >5 mg pred/d) to pose risk of adrenal insufficiency – Hence, Endocrine Society Guideline says short-term glucocorticoid therapy of <3-4 wks, irrespective of dose, DOES NOT require GC tapering buff.ly/4gggMq6

Insomnia is common and frequently occurs with other disorders. First-line cognitive behavioral therapy with or without medication can produce rapid, sustained alleviation of insomnia symptoms. Read the full Clinical Practice article: nej.md/3zMCiBW

More evidence combination DOAC & antiplatelet should not use used together in patients with Atrial Fibrillation and Stable Coronary Artery Disease, as there is no benefit in ischaemic events but significant increase in bleeding risk #ESCCongress #EPIC-CAD nejm.org/doi/full/10.10…

Methadone's  analgesic duration is much shorter than it's anticraving effects when used for opioid use disorder (6 to 8 hours versus >24 hours respectively). When managing acute pain in a patient established on methadone for opioid use disorder the once daily maintenance dose of

Pain referral patterns for the shoulder and examination to differentiate shoulder/neck pathology #shoulder #neck #pain journals.sagepub.com/doi/10.1177/21…

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