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Conserved spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts revealed by single-cell spatial multi-omics dlvr.it/TKm6gd

Excited to share our work developing Elastin-based Nanoparticles for Therapeutic delivERy (ENTER), a non-viral protein nanoparticle system for nucleic acid and protein delivery Nature Biotechnology Elliot Chaikof! A 🧵on the iterative process of engineering ENTER and applications (1/17):

Today in Science Magazine we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells, a collaboration with Sternberg Lab. 1/13 drive.google.com/file/d/1I-UbCR…

The Curated Cancer Cell Atlas provides a comprehensive characterization of tumors at single-cell resolution | Nature Cancer nature.com/articles/s4301…

How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵

Excited to share our comprehensive cell line atlas for biliary tract cancer (BTC) in collab with Dr. Nabeel Bardeesy Mass General Cancer Center & Francisca Vazquez, and led by Vindhya Vijay & Negin Karisani! doi.org/10.1158/2159-8… The Cancer Dependency Map Cancer Discovery Also see: massgeneralbrigham.org/en/about/newsr…

New paper out in Genome Research on using contrastive self-supervised learning for spatial domain detection with multi-omics data! Huge congratulations to Jianing Yao and coauthors Jinglun Yu, Brian Caffo Stephanie Page & Keri Martinowich! 🧬 doi.org/10.1101/gr.279…

Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses go.nature.com/4c9hu6M rdcu.be/em3WN

Integrating ctDNA Analysis and Radiomics for Dynamic Risk Assessment in Localized Lung Cancer. aacrjournals.org/cancerdiscover…

Oncogene aberrations drive medulloblastoma progression, not initiation. nature.com/articles/s4158…

Thrilled to see #SAVANA out in Nature Methods🥳 SAVANA detects haplotype-resolved somatic SVs and copy number aberrations (SCNAs) and infers tumour purity & ploidy in clinical samples using long-read sequencing with or WITHOUT a matched germline control 👇nature.com/articles/s4159…

🚨New paper🚨 Excited to share our latest on nature today: The PIVOT PENALTY in research. nature.com/articles/s4158… More than five years in the making. Key finding: The impact of new research steeply declines the further a researcher moves from their previous work.

GenAI is almost 5x less accurate than humans when summarizing scientific research, according to new study: bit.ly/4dzcDMT

How Good is AlphaFold3 at Ranking Drug Binding Affinities? １．This work explores a compelling question: Can AlphaFold3-like models not only predict structures, but also accurately rank ligand binding affinities? The authors show the answer is yes — with a method that comes

nature.com/articles/s4158…

Detection of cancers three years prior to diagnosis using plasma cell-free DNA aacrjournals.org/cancerdiscover…

The remarkable benefit of exercise was just extended to improved survival after cancer in a randomized trial NEJM #ASCO25 nejm.org/doi/full/10.10…

Pfizer and AstraZeneca’s FLOWR model generates ligands 70× faster with improved structural accuracy by conditioning on protein pocket shapes. The shift from diffusion to flow-based models like FLOWR shows promising gains in speed and precision for drug discovery.

NEW content online! Acquired resistance in cancer: towards targeted therapeutic strategies bit.ly/3SABwye