See our new and updated website detailing our research, current lab members and publications. sites.northwestern.edu/penzeslab #Northwestern Northwestern Feinberg School of Medicine

Come and learn about Penzes lab research at #sfn2019! Poster session Monday 21st, 1-5pm. Theme B neural excitability/synapses and glia. Hall A, 369 - Synaptogenesis and Activity-Dependent Development III

Our new research reveals that mutations in USP9X lead to neuronal, behavioral and clinical abnormalities, and suggest a mechanism important in #intellectualdisability, #autism, #schizophrenia and #bipolar disorder. #penzeslab Northwestern Feinberg School of Medicine cell.com/neuron/fulltex…

Read our new review on iPSC-derived models of autism! This work is focused on the role of excitation/inhibition imbalance and its effect on neuronal development. molecularautism.biomedcentral.com/articles/10.11… #penzeslab #NUFeinbergMed

New research from our lab identifies a direct link between cytokine signalling and ubiquitinase-mediated regulation of the bipolar/ASD/intellectual disability risk gene, Ank3. #Penzeslab #NUFeinbergMed cell.com/cell-reports/f…

Our new work, published in Neuron, provides novel insight into spinule function. Cutting-edge microscopy allows us to probe the formation, stability and regulation of these structures in live neurons, providing insight into their roles in connectivity. cell.com/neuron/fulltex…

Our new paper reveals the role of Homer1 and AnkyrinG in shaping the synapse proteome and controlling dendritic spines. Read it in molpsych! nature.com/articles/s4138…

New research from the Penzes lab! We found schizophrenia risk factor 16p11.2 duplication to cause profound alterations in excitatory iPSC-derived neurons. These effects were present in schizophrenia patient-iPSC, revealing potential pathophysiology. biologicalpsychiatryjournal.com/article/S0006-…

Check out our new preprint on disease mechanisms in the #16p11.2 mouse model! This work uses proteomics to help find a genetic driver of seizure and sociability phenotypes 🐁. biorxiv.org/content/10.110…

If you are interested in #cnv biology and risk factors for #autism and #schizophrenia. Come say hi to Marc's poster on board F23. Now until 5pm @ #SfN2022 !

Come learn about the ank2 synaptic proteome with links to seizure susceptibility. Poster D46 at #SfN2022

Read about our research in the following NU news article; Targeting calcium signaling in neurons represent a promising therapeutic approach in schizophrenia. news.feinberg.northwestern.edu/2023/02/06/pot… Northwestern Feinberg School of Medicine Penzeslab Northwestern Autism & Neurodevelopment NorthwesternResearch

Very proud to announce my work on the 16p11.2 duplication mouse model is now published!! It’s been a looong journey with this guy but so glad it’s finally out there. Click below to learn more about #16p11 #CNV #autism #schizophrenia #epilepsy 🧵1/7 nature.com/articles/s4146…

Northwestern Medicine scientists have identified the cause of a genetic subtype of #Autism and #Schizophrenia that results in social deficits and seizures in mice and humans, research published in Nature Communications. spr.ly/60143I7jE

Our new review on CNVs in neuropsychiatric disorders is now online 💫. Thanks to Current Opinion in Neurobiology for the opportunity to write this. Read below to find out more about genetics and disease mechanisms in #CNVs #16p11 #15q11 #22q11🧵 1/5 doi.org/10.1016/j.conb…

Come see new work from penzes lab members #sfn2024. Saturday afternoon "synapses", poster session B. Jessica Christiansen on novel regulatory sites in schizophrenia risk gene TRIO - poster B67. Marc Forrest on homeostatic plasticity in 16p11.2 duplication - poster B68.

Come see new work from penzes lab members #sfn2024. Saturday afternoon "synapses", poster session B. Nicolas Piguel using expansion microscopy to visualize bipolar risk gene ANK3 - B69. Euan Parnell dissecting novel developmental roles of KALRN in brain development-poster B70.

CAM and Northwestern Autism & Neurodevelopment Northwestern Feinberg School of Medicine Penzeslab have collaborated in acquiring the first MIRAVA Microscope Abberior. One of the first of its kind worldwide, this cutting-edge technology will become operational in spring 2025 at CAM! Department of Cell & Developmental Biology BioImaging North America

Exciting news! The Center for Autism & Neurodevelopment & NU Center for Advanced Microscopy & NIC are acquiring the first MIRAVA POLYSCOPE from Abberior The only microscope combining all imaging scales—from confocal (200 nm) to STED (3D super-resolution) to MINFLUX (3.2 nm precision).Advancing research!

“About 80% of this increase is caused by broader diagnostic criteria... but 20% is not explained by this,” said Dr. Peter Penzes (Penzeslab), director of Northwestern Autism & Neurodevelopment, on the rise in #autism diagnoses over the past decade, in an interview with WTTW - Chicago PBS. tinyurl.com/muaty8cb