The timing of this is not a coincidence-it is purposeful. We will not let this fly under the radar. Every. Single. American. Deserves comprehensive healthcare. No discrimination can be allowed to stand. We must come out en masse and reject this. UPMC

Excited to announce the new Microbiology and Immunology Diversity Scholars (MIDS) Program! MIDS is an undergraduate research initiative established by Pitt Micro/Immuno and aims to engage underrepresented students in biomedical research. Link in bio for more info!

Very proud of my trainees Andrew, Paolo, Kristin, and Mac presenting their work in invited 10 minute and lightning round formats at the University of Pittsburgh Pitt BGSA Student Symposium today! An excellent showing from the lab!

During an address Friday night, Democratic presidential nominee Joe Biden said it's becoming clear voters "chose change," adding: "They've given us a mandate for action on COVID, the economy, climate change, systemic racism." More: cbsloc.al/36docqL

JOE BIDEN DEFEATS PRESIDENT DONALD TRUMP The Associated Press declares Joe Biden the winner of a grueling campaign for the American presidency. He will lead a polarized nation through a historic collision of health, economic and social crises. #APracecall

Excited to be giving Grand Rounds at @NCIResearchCtr on Friday, 11/20 at 12pm! I'll discuss how tumor metabolism promotes the activity of exhausted and regulatory T cells: two papers currently in press! Open to the public, so come check it out: bit.ly/2JKa3tx

With #COVID19 vaccine efficacy of ~95%, I'm looking forward to vaccine distribution in 2021 bringing the pandemic under control. However, I'm concerned that we'll see antigenic drift of SARS-CoV-2 and may need to update the strain used in the vaccine with some regularity. 1/18

I was thrilled to be involved with this project; exploring how hypoxia (lack of available oxygen) in cancer can be targeted to improve cancer cell killing by T cells, with the involved mechanisms well delineated. Exciting and important work by @scharpingne.

Very excited to be presenting my research today at the Global Immunometabolism Forum (IMF) on how #cancer #metabolism enforces immunosuppressive functions in tumor-reactive #Tcells. Delgoffe Lab @DavidFinlayTCD

Congratulations to my friend, President Joe Biden! This is your time.

"For there is always light, If only we are brave enough to see it If only we are brave enough to be it." -Amanda Gorman, National Youth Poet Laureate. Wonderfully written, perfectly delivered. A privilege to listen to her speak at the #Inauguration2021.

A paper in Nature shows that immunosuppressive Treg cells in the tumor microenvironment can preferentially use lactate as a fuel source. go.nature.com/3kbShgS

These data are extra special to me. When I joined as a rotating MSTP student in ‘17, MJW and I spent the summer investigating two stories of immune cells & cancer. This is the 1st, now @nature. We hope to share the 2nd soon. These projects got me hooked on science of Delgoffe Lab

Thanks to all involved, including our four first authors @rhodesf0rd Paolo Vignali, PhD @scharpingne Natalie Rittenhouse, and funding sources including: The Mark Foundation for Cancer Research Cancer Research Institute UPMC Hillman Cancer Center NIH Common Fund!

New insights from PoholekLab, Delgoffe Lab, and colleagues suggest that even the most fatigued T cells can be revived. This opens potential new avenues for cancer immunotherapy that weren't possible before. upmc.com/media/news/080…

#Chromatin modifications and #hypoxia contribute to exhausted T cells in mouse #tumor model, according to University of Pittsburgh researchers⤵️ fcld.ly/epg8con

Can #epigenetic signaling be used to combat T cell exhaustion for cancer #immunotherapy? Here PoholekLab used CUT&RUN + CUT&Tag to characterize #chromatin mechanisms underlying T cell exhaustion - revealing new avenues for drug development. hubs.la/Q01jBj9f0

How to revive an exhausted T cell? University of Pittsburgh scientists explore how T cells in mice become dysfunction in #cancer and how to restore their #antitumor response: fcld.ly/epg8con

In a new Science Immunology study, scientists explore how T cells in mice become dysfunction in #cancer and how to restore their #antitumor response. fcld.ly/5936spa

Excited to share findings of ICG use for SLNB in kids with sarcoma & melanoma! 👉🏽safe 👉🏽combined with technetium, ICG more reliably identified radioactive LNs vs blue dye sciencedirect.com/science/articl… Marcus Malek Pitt Pediatric Surgery Pitt Surgery Brittani Seynnaeve, MD, MS Kurt Weiss Paolo Vignali, PhD