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🌟🎓👏👏👏Brilliant work by Tom Powles on the #NIAGARA ctDNA exploratory analysis 🔬 at #ASCO25 OncoAlert 🟠 ctDNA+ rate: 57% (baseline) → 22% (pre-RC) → 9% (post-RC) 🟠 Pre-RC ctDNA+ strongly correlated with non-pCR (97%) 🟠 ctDNA clearance: 41% (D+NAC) vs 31% (NAC) 🟠 EFS

📢 #ASCO25 | ANZUP 1301 Ph III | HR NMIBC (~500 pts): Mitomycin + BCG vs BCG alone—combination arm met primary endpoint with significant DFS benefit (HR 0.70; 2‑yr DFS 78% vs 65%); recurrence reduced. Dickon Hayne et al. Full abstract → asco.org/abstracts-pres…

This is a major story from #ASCO25. Randomized phase 3 trial of time of day of immunotherapy infusion. Randomized to infusion before or after 3pm. Early infusion far superior: PFS 11.3 vs 5.7 HR 0.42, OS HR 0.45! Impactful, pragmatic, not costly. This should be a bigger story.

EXTEND showed us that MDT + ADT > ADT RADIOSA showed MDT + ADT > MDT. STORM / PEACE-V showed ENI + MDT + ADT > MDT + ADT All studies had some novel imaging defined mHSPC (STORM was 100% novel) Can we just accept that MDT (+/- elective RT) + ADT is better than either?!?

🔥NSABP- B51 is out! Practice changing trial supporting RT de-escalation in cN1, ypN0 breast cancer 👉longer follow up desired 👉applicability across subtypes? 👉Impact of more modern systemic therapies ? NRG Oncology ASTRO #BreastCancer nejm.org/doi/full/10.10…

Complete vs partial TURBT for #MIBC treatment. fredrik liedberg, Marco Moschini, & Benjamin Pradere join Ashish M. Kamat, MD, MBBS in this discussion on the extent of transurethral resection of bladder tumor (TURBT) needed in muscle-invasive #BladderCancer. #WatchNow on UroToday >

💙 We close #WorldProstateCancerDay with a new publication! 📄 Just out in TAU (May 2025): 🔗 tau.amegroups.org/issue/view/1497 Proud to keep moving the field forward for men facing prostate cancer. #Oncology 🎯 #TAU #Radiotherapy ⚡ Paul Sargos Fernando Lopez Campos Dr González

How to optimize treatment for patients with non-muscle-invasive bladder cancer (NMIBC): Morgan Roupret Vérane Achard Félix Guerrero-Ramos - Intensification with systemic immunotherapy in addition to BCG in BCG-naïve patients? What can we learn from CREST and ALBAN trials?

- BCG-unresponsive NMIBC: What about new conservative strategies? Does radiotherapy have a place? - Cystectomy as a standard treatment: How to improve our oncological and functional outcomes?

Join the debate by joining us at the @FOCUS_meeting Toulouse, October 9-10 Registration: focus-meeting.fr joaquim bellmunt Enrique Grande Benjamin Pradere Gautier Marcq Elena Castro Karim Bensalah Jb Beauval Pignot Géraldine Ploussard Guillaume Pouessel Damien Roubaud Guilhem @MRoumiguie Paul Sargos

Thanks Sophia Kamran, MD & Constantinos Zamboglou for this invitation to highlight keypoints and thoughts about ADT and Post-op RT. sciencedirect.com/science/articl… ✨✨✨✨✨✨✨✨✨✨

Paul Sargos Sophia Kamran, MD Constantinos Zamboglou Vérane Achard Alan Dal Pra, MD GETUG Association Française d'Urologie - AFU AFUF SFjRO ESTRO European Association of Urology (EAU) Very well written editorial, well balanced.

Honored to be a co-editor along with Constantinos Zamboglou for this Issue on Prostate Cancer, now available in Seminars in Radiation Oncology. Thank you to @ANViswanathan for the invitation and support. 1/n

Paul Sargos ; Vérane Achard ; Alan Dal Pra, MD ; Abhishek Solanki ; Dr. Jason Efstathiou ; Krishnan Patel, MD, MHS ; Ravi A Madan M.D. ; Deborah Citrin 9/n

Huge thank you to all who participated – apologies if I missed your tag! Also big thank you to all those not on X. 🙏 We hope that these articles are useful and interesting. Thank you!! /fin

Postoperative Radiation and Hormonal Therapy in the Management of Prostate Cancer - Paul Sargos Paul Sargos Sophia Kamran, MD Constantinos Zamboglou oncodaily.com/blog/paul-sarg… #OncoDaily #Oncology #Cancer #Health #Medicine #MedTwitter #MedEd #MedOnc #MedNews #ProstateCancer

1️⃣ Elective Regional Nodal Irradiation in Prostate Cancer 👥 With Dr Srinivas Chilukuri, Mutlay Sayan, MD & Alan Dal Pra, MD 🎯 We cover rationale, patient selection & key trials shaping WPRT in high-risk, SBRT and post op settings. Read 📖 doi.org/10.1016/j.semr…

2️⃣ Metastasis Directed Therapy in Oligometastatic Prostate Cancer 👥 With Maneesh Singh & Piet Ost 🧠 A deep dive into MDT’s role: trial data, timing, integration with systemic Rx. 🚀 Covering both HSPC and CRPC. Read 📖 doi.org/10.1016/j.semr… With an image for the ages!