Paul Karanicolas (@paulkaranicolas) 's Twitter Profile
Paul Karanicolas

@paulkaranicolas

Surgical Oncologist specializing in liver, pancreatic, stomach, and colorectal cancer. Clinical trialist. Evidence-based medicine advocate. Proud Canadian.

ID: 596030936

calendar_today01-06-2012 02:16:45

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Gordon H. Guyatt (@guyattgh) 's Twitter Profile Photo

If they have expertise, academics should contribute to critical social discourse. Major stream of my life: advocating for Canadian publicly funded, universal, high quality health care. Latest effort: article in Canada’s largest circulation newspaper. bit.ly/3BfRynS

UofT Surgical Oncology (@uoftsurgonc) 's Twitter Profile Photo

« Leaders leave leaders behind » - tonight we celebrated Frances Wright 12-year tenure as Surg Onc program director U of T Department of Surgery during which time we trained over 50 fellows from the Americas, Europe, Africa, Asia, Australia, and the Middle East. Thank you Dr Wright!

« Leaders leave leaders behind » - tonight we celebrated <a href="/FrancesWright15/">Frances Wright</a> 12-year tenure as Surg Onc program director <a href="/UofTSurgery/">U of T Department of Surgery</a> during which time we trained over 50 fellows from the Americas, Europe, Africa, Asia, Australia, and the Middle East. Thank you Dr Wright!
Flavio G Rocha, MD, FACS, FSSO (@flaviorochamd) 's Twitter Profile Photo

It with great sadness that we say goodbye to Professor Leslie H Blumgart, a true legend of #HPB surgery who developed the field around the 🌍 Many of us remember his dedication to the teaching of Memorial Sloan Kettering Cancer Center surgical fellows who proudly carry on his legacy. Legends Of Surgery

It with great sadness that we say goodbye to Professor Leslie H Blumgart, a true legend of #HPB surgery who developed the field around the 🌍  Many of us remember his dedication to the teaching of <a href="/MSKCancerCenter/">Memorial Sloan Kettering Cancer Center</a> surgical fellows who proudly carry on his legacy. <a href="/SurgeryLegends/">Legends Of Surgery</a>
Gordon H. Guyatt (@guyattgh) 's Twitter Profile Photo

From its inception, EBM has had its critics. In 2008 we were asked to engage in a debate about whether EBM has a sound scientific basis. The paper we wrote for the debate presents one of the nicest explanations of the role of EBM and what it offers. doi.org/10.1378/chest.…

Canadian Hepato-Pancreato-Biliary Association (@chpbasurg) 's Twitter Profile Photo

Investigators meeting after completion of the HELIX trial today at #AHPBA23 Powerful collaboration across 1⃣1⃣sites 1⃣3⃣8⃣4⃣pts randomized 5⃣1⃣% eligible pts consented One of the largest trials in liver surgery. Congrats Paul Karanicolas and team! Results? 🤫... stay tuned!

Investigators meeting after completion of the HELIX trial today at #AHPBA23
Powerful collaboration across 1⃣1⃣sites
1⃣3⃣8⃣4⃣pts randomized
5⃣1⃣% eligible pts consented
One of the largest trials in liver surgery. Congrats <a href="/PaulKaranicolas/">Paul Karanicolas</a> and team!

Results? 🤫... stay tuned!
Canadian Hepato-Pancreato-Biliary Association (@chpbasurg) 's Twitter Profile Photo

👀Toronto experience with #LDLT for unresectable #CRLM by Luckshi Rajendran #AHPBA23 - prospective trial in 🇨🇦 ▪️3⃣6⃣eligible➡️7⃣transplanted+9⃣ongoing w-u ▪️Good early oncologic outcomes ▪️Option in highly-selected population Gonzalo Sapisochin UofT General Surgery U of T Department of Surgery Ajmera Transplant Centre UHN AHPBA

👀Toronto experience with #LDLT for unresectable #CRLM by <a href="/lucksheee/">Luckshi Rajendran</a> #AHPBA23 - prospective trial in 🇨🇦

▪️3⃣6⃣eligible➡️7⃣transplanted+9⃣ongoing w-u
▪️Good early oncologic outcomes
▪️Option in highly-selected population

<a href="/sapisochin/">Gonzalo Sapisochin</a> <a href="/UofTGSx/">UofT General Surgery</a> <a href="/UofTSurgery/">U of T Department of Surgery</a> <a href="/UHNTransplant/">Ajmera Transplant Centre UHN</a> <a href="/AHPBA/">AHPBA</a>
Julie Hallet (@halletjulie) 's Twitter Profile Photo

🚨First registry-linked collaborative RCT using NSQIP AHPBA American College of Surgeons ⭐️Pip-taz for antibioprophylaxis in whipple👉🏻⬇️ 30-day SSI in RCT ⭐️New standard of care & new way to run multi-centre trials 👏🏻Congrats everyone! Michael D’Angelica jamanetwork.com/journals/jama/…

CIHR (@cihr_irsc) 's Twitter Profile Photo

Washing surgery wounds is necessary, but we still don’t know the most effective method. Paul Karanicolas is evaluating the best practice for keeping surgical wounds clean and avoiding infection. Learn about the #ClinicalTrial: cihr-irsc.gc.ca/e/53357.html?f… Sunnybrook Health Sciences Centre U of T Department of Surgery

Washing surgery wounds is necessary, but we still don’t know the most effective method.

<a href="/PaulKaranicolas/">Paul Karanicolas</a> is evaluating the best practice for keeping surgical wounds clean and avoiding infection.

Learn about the #ClinicalTrial: cihr-irsc.gc.ca/e/53357.html?f…

<a href="/Sunnybrook/">Sunnybrook Health Sciences Centre</a> <a href="/UofTSurgery/">U of T Department of Surgery</a>
U of T Department of Surgery (@uoftsurgery) 's Twitter Profile Photo

📢Congratulations to Dr. Sean P. Cleary, who has been appointed as Bernard & Ryna Langer Chair, Division of General Surgery at U of T Department of Surgery. Read more about it here: surgery.utoronto.ca/SeanClearyGene…

📢Congratulations to Dr. Sean P. Cleary, who has been appointed as Bernard &amp; Ryna Langer Chair, Division of General Surgery at <a href="/UofTSurgery/">U of T Department of Surgery</a>. 
Read more about it here: surgery.utoronto.ca/SeanClearyGene…
Kari Tikkinen (@karitikkinen) 's Twitter Profile Photo

🔥 PRACTICE CHANGING EVIDENCE 🔥 Annals of Surgery just published, online ahead of final publication, abdominal surgery results of the ROTBIGGS project What are procedure-specific risk estimates for #VTE & major #bleeding in general abdominal #surgery? #EBM 🧵1/10

🔥 PRACTICE CHANGING EVIDENCE 🔥

<a href="/AnnalsofSurgery/">Annals of Surgery</a> just published, online ahead of final publication, abdominal surgery results of the ROTBIGGS project 

What are procedure-specific risk estimates for #VTE &amp; major #bleeding in general abdominal #surgery? #EBM

🧵1/10
UofT Surgical Oncology (@uoftsurgonc) 's Twitter Profile Photo

Surg onc/HPB fellow Alejandro Branes at #AHPBA24 Unplanned ICU admission after hepatectomy (from #HELIX data) ▪️⬆️ mortality ▪️Associated with comorbidities,🩸>500cc & major resection ⚠️Close monitoring with these risk factors needed

Surg onc/HPB fellow Alejandro Branes at #AHPBA24

Unplanned ICU admission after  hepatectomy (from #HELIX data)
▪️⬆️ mortality
▪️Associated with comorbidities,🩸&gt;500cc &amp; major resection

⚠️Close monitoring with these risk factors needed
UofT Surgical Oncology (@uoftsurgonc) 's Twitter Profile Photo

Surg onc/HPB fellow Sasha Acher at #AHPBA2024 #AHPBA24 Hepatic inflow occlusion for liver resection ▪️Variability between surgeons ▪️No association with periop 🩸transfusion ▪️No association with postop morbidity ➡️Further work needed to understand use by surgeons & impact

Surg onc/HPB fellow Sasha Acher at #AHPBA2024 #AHPBA24 

Hepatic inflow occlusion for liver resection 
▪️Variability between surgeons
▪️No association with periop 🩸transfusion
▪️No association with postop morbidity 

➡️Further work needed to understand use by surgeons &amp; impact
Julie Hallet (@halletjulie) 's Twitter Profile Photo

Kicking off Yuman Fong visit to U of T Department of Surgery as Hanna visiting professor with journal club by UofT Surgical Oncology fellows ctDNA🧬: ready for clinical practice for CRLM? ❌ preop does not change management 🔪hepatectomy can convert ➕ve👉🏻➖ve For now: better use of💰to get CEA?😳

Kicking off <a href="/SoCalYuman/">Yuman Fong</a> visit to <a href="/UofTSurgery/">U of T Department of Surgery</a> as  Hanna visiting professor with journal club by <a href="/UofTSurgOnc/">UofT Surgical Oncology</a> fellows

ctDNA🧬: ready for clinical practice for CRLM? 
❌ preop does not change management
🔪hepatectomy can convert ➕ve👉🏻➖ve  

For now: better use of💰to get CEA?😳
Paul Karanicolas (@paulkaranicolas) 's Twitter Profile Photo

Thank you Yuman Fong for an inspiring, educational visit as our Hanna Visiting Professor U of T Department of Surgery Sunnybrook Health Sciences Centre! We loved spending time with you and learning about everything from hepatectomy to gene surgery to coaching. Your knowledge is endless!!!

Thank you <a href="/SoCalYuman/">Yuman Fong</a> for an inspiring, educational visit as our Hanna Visiting Professor <a href="/UofTSurgery/">U of T Department of Surgery</a> <a href="/Sunnybrook/">Sunnybrook Health Sciences Centre</a>! We loved spending time with you and learning about everything from hepatectomy to gene surgery to coaching. Your knowledge is endless!!!
Julie Hallet (@halletjulie) 's Twitter Profile Photo

❌ TXA for liver resection #HELIX out in JAMA 👥1384 pts 🏥11 centres TXA 🆚 placebo No difference🩸transfusion But ⬆️ complications with TXA ⚠️Stop (or don’t start?) using it 🔗👇🏻

❌ TXA for liver resection

#HELIX out in <a href="/JAMA_current/">JAMA</a> 
👥1384 pts
🏥11 centres 
TXA 🆚 placebo
No difference🩸transfusion
But ⬆️ complications with TXA
 
⚠️Stop (or don’t start?) using it

🔗👇🏻
Paul Karanicolas (@paulkaranicolas) 's Twitter Profile Photo

Thanks to all the amazing patients, surgeons, and researchers who made this trial possible. TXA did not reduce bleeding or blood transfusion but increased periop complications after liver resection. ⁦JAMA⁩ jamanetwork.com/journals/jama/…