#MayoIDFellowship Grand Rounds Novel antifungal drugs and diagnostics presented by Dr. Pascalis Vergidis MD, MSc Vergidis

Physicians are problem solvers (nothing else)

ID Grand Rounds Mayo Clinic Infectious Diseases I discussed the following: - ONE Health - Aspergillus urine antigen - Giant magnetoresistance-enabled PCR - Rezafungin for prevention in bone marrow transplant - Ibrexafungerp (FURI) - Olorofim (Study 32) - Our experience with fosmanogepix

My recent work on display ESCMID ESCMID Fungal Infection Study Group (EFISG) looked at rising fluconazole resistance in C. parapsilosis. Our reference lab Mayo Clinic Infectious Diseases has seen a (concerning!) rise in fluconazole resistance from ~5-10% to 20% in the past 3 years. Thanks Pascalis Vergidis MD, MSc for mentorship.

“No government—regardless of which party is in power—should dictate what private universities can teach, whom they can admit and hire, and which areas of study and inquiry they can pursue.” - President Alan Garber hrvd.me/GarberRespond3…

New manuscript in Journal of Infectious Diseases - we report a concerning rise in fluconazole resistance in Candida parapsilosis bloodstream isolates at our (referral) lab over the past several years. Consider susceptibility testing prior to transitioning to fluconazole. academic.oup.com/jid/advance-ar…

Congrats Jack🎉 Important study Mayo Clinic Infectious Diseases Pascalis Vergidis MD, MSc S. Mac Chesdachai MSGERC

"As a pediatrician and an infectious diseases specialist, I want every child to thrive. Vaccines are one of the most powerful, safe and effective tools we have to make that possible," says IDSA President Tina Tan, MD, FIDSA, FPIDS, FAAP. IDSA responds to the MAHA report:

In a phase 3 clinical trial, pemivibart provided prophylactic efficacy against COVID-19 in immunocompromised patients and individuals at risk for exposure. Four of 623 participants experienced anaphylactic reactions Clinical Infectious Diseases transplantid.net academic.oup.com/cid/advance-ar…

High Kaposi sarcoma-associated herpesvirus seroprevalence in donors and recipients with HIV, particularly among MSM. Reassuringly, disease was rare Clinical Infectious Diseases transplantid.net academic.oup.com/cid/advance-ar…

Dr. Jeniel Nett discussing biofilm at the 2025 Scientific Meeting on Candida auris MSGERC Successful meeting held in Miami.

Synthesis of the available literature on the use of CMV-specific T-cell therapy in adult and pediatric HSCT and SOT recipients. Several patients on concurrent antivirals, which confounded the effectiveness of VSTs Clinical Infectious Diseases transplantid.net academic.oup.com/cid/advance-ar…

Visited the historic city of Philadelphia to attend the American Board of Internal Medicine (ABIM) New Governance Orientation. Looking forward to serving on the Infectious Disease Approval Committee. Of the profession, for the public American Board of Internal Medicine (ABIM)

Join us for a panel discussion on “Leveraging Partnerships to Fight Fungal Diseases” ASM Dallas Smith CDC Sean Zhang, Fungal Diagnostics Laboratory Consortium Rob Purdie, MYCology Advocacy, Research & Education Zachary Rubin LA Public Health Me MSGERC

🔥🗞️Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study. Groundbreaking work on a very promising new antifungal. Free access here: authors.elsevier.com/c/1lHca5E-UokK…

【Blastemia portrays a poor prognosis in acute leukemia patients with invasive pulmonary aspergillosis】 Excited to share our recent article on the “B-index” in invasive pulmonary aspergillosis! MD Anderson Cancer Center In addition to the D-index, blastemia is an important prognostic

I learned a lot by attending the lecture of Dallas Smith CDC on chromoblastomycosis and eumycetoma. ASM Microbe 2025

Thursday AM conference at Mayo Clinic Infectious Diseases where our excellent senior fellows Melissa Kerkelis and Jack McHugh present 6 rapid review cases. At our fellowship, Thursday AM conference presents one of the many opportunities for fellows/residents to teach the division. 📖 👓