
Pascal Vos
@pascal_d_vos
Research Associate | Laboratory of Synthetic Biology and Drug Discovery | Harry Perkins Institute of Medical Research | Curtin University.
ID: 803214815997005824
28-11-2016 12:31:49
15 Tweet
22 Followers
24 Following



Organization and expression of the mammalian mitochondrial genome go.nature.com/3MqLEV0 #Review by Oliver Rackham & Aleksandra Filipovska

My first research paper from my PhD is officially out now! Cas9 is now officially gone into hyperdrive with our newly designed TurboCas9. Oliver Rackham Aleksandra Filipovska nature.com/articles/s4146… #Cas9 #Synbio #

Ready to shred DNA with a hyperactive Cas9? We used artificial genetic circuits in yeast to test computationally designed Cas9 variants and found TurboCas9 that can introduce large and diverse indels in mammalian cells. Free to read Nature Communications: rdcu.be/cOFkX #CRISPR



Trick or Treat? Oliver Rackham explore Frankenstein Cas9 variants and the latest developments in engineering Cas9 for improved gene editing in a new #BiochemSocTrans mini review doi.org/10.1042/BST202…






High-fidelity Cas9 variants that prevent off-target cleavage typically reduce on-target activity. Adding TurboCas9 mutations to these enzymes can improve activity while maintaining off-target fidelity. Cell Reports Methods cell.com/cell-reports-m…


Better CRISPR base editors! More efficient nicking of the unedited DNA strand improves the ability to edit hard to reach bases. ACS Synthetic Bio pubs.acs.org/doi/10.1021/ac…
