We revealed that DPANN YN1 is deficient in essential metabolic processes and requires host resources to proliferate. CryoET revealed an enormous attachment organelle in the DPANN envelope that bridges the DPANN and host cytoplasms for intercellular exchange.

A neuronal growth cone photographed through an electron microscope. I removed the microtubules after extraction but before fixation. Otherwise, all of the fine actin filament based structures in the middle (i.e., Central domain) would be obscured by microtubules. #CellBiology

Last week we released Amira-Avizo 2024.1! Tomorrow we are hosting a live webinar reviewing updates to our software. Two times, both on June 11th. Click through to register. ter.li/3shwux bit.ly/3RkwXro

Join us on June 26 at 10 AM EST/4 PM CEST for a webinar on mitochondrial architecture using cryo-ET! High Resolution Investigation of Mitochondrial Molecular Architecture Free to attend, register now! ter.li/mlzh8q #Webinar #StructuralBiology bit.ly/4b1fs6v

This is awesome! Excited to have another resource to point people to for segmentation help!

This is so cool! Can't wait to try it out

Superstar inaugural Manor Lab postdoc Cara's new paper is up! Here we show ER-actin accumulates at ER-organelle contacts to regulate their fission and mobility. This applies to mitos, lysos, and endosomes, and is mediated by INF2, an ER-anchored formin. biorxiv.org/content/10.110…

bit.ly/466u3gd

This is the big one!🤩 Opening for an awesome group leader to join our community on the 5th/6th floor of the Biozentrum, University of Basel. We're looking for someone who brings an exiting biological program using a combo of structural biology, cellular imaging, and biophysics. 📢Retweet please!

I would love to hang out with people at #MM2024 ! DM or poke me here, whatever works. I'm up for coffee, a meal, just chatting... going to the zoo...

Cleveland! Ready for #MM2024 My talk on in situ structrual biology is on Tuesday at 2:30, session B01.2 Room 12! But I'd love to hang out outside of the talk as well! Grab me in the hall, find me haunting the Thermo Fisher booth, reach out!

bit.ly/4fWyHlh

If you're at EMC2024 and want to grab coffee or hang out, hit me up!

Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.110…

🚀 Exciting opportunities alert! 🚀 I’m looking for talented individuals to join my team. If you have a passion for compute system administration and cryo-EM, we have a senior role in Netherlands that could be perfect for you! #ComputeAdmin #CryoEM jobs.thermofisher.com/global/en/job/…

Anyone know of a program that can take a STAR file and a STA structure and map the structure back to the tomogram at the correct orientations? But then can go one step further and turn that into a volumetric segmentation? The last step seems to be the hardest to find....

Thank you for the warm welcome! I’m excited to join the incredible team & continue advancing #CryoEM and #CryoET. A heartfelt thank you to my amazing team & colleagues at Microscopy & Spectroscopy for an unforgettable journey the last 7 years. Ready to build on that momentum at St. Jude!

Have you ever analyzed a #microscope image before- even just a single one? Please take our survey on progress and places to still improve for image analysis software! #microscopy #imageanalysis #bioimageanalysis forum.image.sc/t/2024-image-a…

🚨 Attention PhD students! 🚨 We have a 12-week paid internship opportunity at Genentech. Want to see how we use cryo-ET in pharma and spend summer 2025 in the Bay Area? Details and application link here: roche.wd3.myworkdayjobs.com/ROG-A2O-GENE/j… Questions? DM me. Please RT & share! #teamtomo

This has been such an incredibly fun project to help with. I have learned so much and I'm so excited to see it out!