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Droplet microfluidics–based detection of rare antibiotic-resistant subpopulations in Escherichia coli from bloodstream infections "The growth of rare resistant cells is detected by observing droplet shrinkage" science.org/doi/10.1126/sc…

Engineered Lactiplantibacillus plantarum WCFS1 as a Biosensor Probe for Lung Cancer "engineered biosensor detects proteases secreted by lung tumors" pubs.acs.org/doi/10.1021/ac…

Flow-induced 2D nanomaterials intercalated aligned bacterial cellulose "For our bioreactor configuration and a growth period of 10 days, the dry cellulose sheet yield was determined to be ~7.5 mg/day." nature.com/articles/s4146…

Morphology engineering facilitates constructing efficient cell factories "... review the morphology regulation mechanisms in key industrial microorganisms to improve product yields" sciencedirect.com/science/articl…

Advanced research and exploration of CRISPR technology in the field of directed evolution sciencedirect.com/science/articl…

Wearing bacteriophages individually with an adhesive drug-loadable nanohelmet for treating ocular infections "drug-loaded helmeted phages as eye drops for treating ocular infections" science.org/doi/10.1126/sc…

Escherichia coli selection strains for growth-coupled metabolic engineering "growth-coupled selection brings synthetic metabolism to life" sciencedirect.com/science/articl…

"genome shuffling by protoplast fusion between genetically diverse Bacillus strains generates frequent, unbiased, genome-wide recombination that mimics the effects of sexual recombination. ... we leveraged protoplast fusion to establish a bacterial QTL mapping platform"

"there was little overlap between the substitutions found by directed evolution of the RamR transcription factor and those predicted by ML-based tools. ML-designed protein variants tested proved not to be functional."

Beyond nature's clock: Accelerating genomic diversity through hypermutation Targeted mutagenesis technologies sciencedirect.com/science/articl…

Excited to share our labs latest paper. We use #synbio for biosensor discovery to aid our quest to build 'smart probiotics' to sense and treat disease. Well done Clare Robinson et al! Thanks Wellcome for funding! embopress.org/doi/full/10.10… Imperial Department of Infectious Disease The Francis Crick Institute

Construction and phenotypic classification of synthetic dual-pole Escherichia coli cells "a genetic circuit that enables two distinct scaffolding proteins to localize at opposite poles in E. coli" nature.com/articles/s4200…

New review article with Michael Desai is out today! Grateful for the opportunity to contribute something we hope will serve the community well

The extended mobility of plasmids "conjugative transfer and plasmid-encoded advantages can sustain plasmid prevalence despite the plasmid paradox. Microbiome engineering is shifting to precision interventions at the strain, plasmid, or gene level." academic.oup.com/nar/article/53…

Implementation of convolutional neural networks for microbial colony recognition "deep learning for microbial colony recognition to identify unknown strains" journals.asm.org/doi/full/10.11…

"high-throughput phage isolation using droplet microfluidics" PRISM: A platform for illuminating viral dark matter biorxiv.org/content/10.110…

Happy to share that the final chapter from my PhD is now published! We engineered a phage λ mutant to remove its lysogenic potential and deliver an all-in-one CRISPR-associated transposon (CAST) system for targeted gene insertion within E. coli. doi.org/10.1073/pnas.2…

"a synthetic consortium by coculturing C. beijerinckii with an engineered E. coli strain expressing xylanase from an unculturable bacteria, enabling isopropanol production from hemicellulose without requiring anaerobic conditions." pnas.org/doi/10.1073/pn…

Magnetically induced magnetosome chain (MAGiC): A biogenic magnetic-particle-imaging tracer with high performance and navigability "the development of trackable magnetic microrobots in GI tract using isolated magnetosomes from magnetotactic bacteria" science.org/doi/10.1126/sc…

Bacterial two-hybrid systems evolved: innovations for protein-protein interaction research journals.asm.org/doi/full/10.11…