Beautiful simulation work by @fiona_chembot shows structural & dynamical mechanisms of transmissible Paxlovid-resistant SARS-CoV-2 variants w/ The Harris Lab Tim Palzkill Lab science.org/doi/10.1126/sc…

See our recent work in Journal of Biological Chemistry on CTX-M beta-lactamase and its highly optimized cefotaximase function: jbc.org/article/S0021-…

Check out our recently published work from graduate student Lynn Su on Norovirus epitopes for potential vaccine targets: nature.com/articles/s4154…

Dr. Cristina Materon recently published a review on polymyxin resistance mediated by MCR-1 sciencedirect.com/science/articl…

A new type of SARS-CoV-2 Mpro inhibitor is discovered by DNA-encoded chemical library screening, reported by BCMHouston & Damian Young & Srinivas Chamakuri & Tim Palzkill Lab nature.com/articles/s4200…

So happy to share this story and that I was able to play a small part in it! We discovered and validated highly potent small molecule inhibitors of the SARS-CoV-2 main protease, including variants that show resistance to current antiviral treatments.

Jane Park will be defending her thesis tomorrow at 2 PM—be sure to come by or tune in!

We have a second dissertation this week! Lynn Su will defend her dissertation tomorrow at 2 PM, and you can listen in person or via Zoom.

Check out our recently published work on the proposed mechanism of how KPC-44 acquires ceftazidime-avibactam resistance: doi.org/10.1016/j.jbc.…

Some work by my labmates Tim Palzkill Lab that I helped with during my PhD went live over the holidays! We used DNA-encoded libraries to find highly potent inhibitors of two prominent carbapenemases, NDM-1 and OXA-48. pubs.acs.org/doi/abs/10.102…

Check out our latest publication in the Journal of Medicinal Chemistry about the use of DNA encoded libraries to discover novel beta-lactamase inhibitors. doi.org/10.1021/acs.jm… JiayiFan Timothy Palzkill

A happy gathering of our lab group at the Biochemistry and Molecular Pharmacology Holiday Luncheon. 🎄

50,000+ enzyme variants tested. A new catalytic mechanism. A highly interconnected, substrate-dependent network of amino acid interactions discovered. Blood, sweat, tears (mine). This story has it all, folks: pnas.org/doi/10.1073/pn… PNASNews Tim Palzkill Lab

Check out our latest publication in PNAS about using large-scale deep mutational scanning to study epistatic interactions in an enzyme active site. Great work done by @itsDrAllie. doi.org/10.1073/pnas.2…

Congratulations to Jiayi Fan for winning first place for Poster Presentations in the BCM GSBS Symposium, great work!

Well, now it feels officially, officially official (I think it’s the hat)

🎓🌟 Big shout out to Dr. Allison (Allie) Judge , Dr. Lynn Su, and Dr. Jane Park, former lab graduates, who rocked the stage at the recent hooding ceremony, donning their well-deserved hooding hats! 🎩👏 Keep shining bright, champs! 💫 #Graduation #BCM

Congratulations to Michael A. Lopez, a second-year graduate student in the Palzkill Lab, for being awarded the Training Interdisciplinary Pharmacology Scientists Program (TIPS) predoctoral fellowship! Your hard work and dedication are truly commendable.