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Farrar et al. find that the extent of widespread pain is an important factor in the response of patients with interstitial cystitis/bladder pain syndrome to local or widespread symptom therapies. Learn more in #PAIN bit.ly/3RlnHmy

Now in #PAIN: “Widespread pain phenotypes impact treatment efficacy results in randomized clinical trials for interstitial cystitis/bladder pain syndrome: a Multidisciplinary Approach to the Study of Chronic Pelvic Pain network study” by Farrar et al. bit.ly/3RlnHmy

In our new PAIN Journal paper, Jakub Nastaj and colleagues show—for the first time—that not only pain intensity but also pain distribution can be classically conditioned. Both classical conditioning (with/without verbal suggestion) and verbal suggestion alone led to an

Follow us on Bluesky for the latest updates on pain research, treatment, and management: bit.ly/4ii7HgI

Bavencoffe et al. find that hyperexcitability in nociceptor somata isolated from ganglia innervating painful and nonpainful regions suggests new functions for widespread, ongoing nociceptor activity. Learn more in #PAIN bit.ly/3G4Y5rB

The May 2025 issue of #PAIN is out now! Catch up on the latest pain research at bit.ly/3UtFEBe

In this week’s #PAIN Featured Image, @anninabschmid et al.’s immunofluorescence analysis reveals demyelination in Morton’s neuroma. Learn more at bit.ly/4jxqTaC

Combining pain-profiling with RNA sequencing and immunohistochemistry of Morton’s neuroma and non-injured nerves, @anninabschmid et al. identify an ongoing role for intraneural inflammation in chronic peripheral neuropathic pain. Learn more in #PAIN bit.ly/4jxqTaC

Li et al. find that real α-transcranial alternating current stimulation mitigated pain perception by augmenting somatosensory α1-oscillations but amplified pain perception by enhancing midfrontal θ-oscillations. Learn more in #PAIN bit.ly/3G8bGhQ

Our Bluesky community is growing fast! Follow us for updates on cutting-edge pain treatment and management: bit.ly/4ii7HgI

Now in #PAIN: “Social determinants of health in pediatric chronic postsurgical pain research” by Jennifer Rabbitts et al. bit.ly/4jEzlFy

Follow us on Bluesky for the latest updates on pain research, treatment, and management: bit.ly/4ii7HgI

The June 2025 issue of #PAIN is out now! Catch up on the latest pain research at bit.ly/4e5DVZV

In this week’s #PAIN Featured Image, Barnet et al. present a schematic representation of their experimental design. Central TCC sensitization and cephalic hypersensitivity in female rats post-ovariectomy are modulated by the estrous cycle. Learn more at bit.ly/4klpuVg

Barnet et al. find that dural inflammations during high estrogen phases in female rats affect mechanical sensitivity, increase c-Fos in trigemino-cervical complex (TCC) neurons, and enhance excitatory synaptic inputs to TCC neurons #PAIN bit.ly/4klpuVg

Our Bluesky community is growing fast! Follow us for updates on cutting-edge pain treatment and management: bit.ly/4ii7HgI

In Resch et al.’s new human cold pain model, inhibition of transient receptor potential, TRPA1 TRPM8, and voltage-gated sodium channel, type NaV1.7 and NaV1.8, affects noxious cold thresholds but not pain from prolonged cold exposure. Learn more in #PAIN bit.ly/4moiA3p

Now in #PAIN: “Human cold pain: a randomized crossover trial” by Resch et al. bit.ly/4moiA3p

Grant et al. present a realist review investigating factors affecting uptake, implementation, and sustainability of rural pain care. Read the full Editor’s Choice article in #PAIN bit.ly/4j5tkAC

The June cover of #PAIN represents the device used in Vatsi M. Adamczyk et al.’s study of pain radiation. Learn more bit.ly/3S0LTuS