Patrick Harris
@padstamundo
Infectious Diseases Physician, Microbiologist and Research Fellow @UQMedicine. Views all my own.
ID:379388778
https://researchers.uq.edu.au/researcher/19931 24-09-2011 21:42:10
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Feel free to register and join online (or in person in Brisbane) for our latest genomics seminar UQ Medicine; industry partners presenting on new developments in clinical genomics - for both human and microbial applications Illumina Oxford Nanopore QIAGEN
eventbrite.com.au/e/uqccr-industβ¦
#ECCMID2024 Esther van Kleef: cluster RCT community-based bundle to reduce ESBL transmission in Burkina-Faso; 238 households, 4-5 per household; adjusted OR acquisition in intervention households vs non-intervention=1.23 [95% CI: 0.74 - 2.01]), so no clear effect alas
#ECCMID2024 Turner, DOTS RCT; dalbavancin vs SOC for complex SAB; DOOR scale as prim outcome 1-5 (5 =death); QoL score tie-breaker; 23 sites in N America, 200 randomised; included IVDU; balanced MSSA/MRSA; no difference in DOOR outcome but fewer AEs vs SOC
#ECCMID2024 Brett Mitchell: CLEEN study, stepped wedge RCT, 5,002 participants; cleaning bundle intervention associated with a significant reduction in HAIs, OR 0.61 (95%CI 0.47-0.81, p<0.001); cleaning of shared med equipment seems important, high baseline HAI rate (17%)
New publication from Anna Maria Peri UQ News David Paterson UQ Medicine : Network meta-analysis including 25,682 patient events suggests rapid diagnostic tests may have mortality benefit when associated with effective antimicrobial stewardship pubmed.ncbi.nlm.nih.gov/38676943/
A study presented by Abdullah Tarik Aslan at #ESCMIDGlobal2024
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Is Pip-tazo-Teicoplanin use associated with increased risk for AKI?
David Paterson Patrick Harris
Kind of mind-bending the incredible progress being made in metagenomics-based clinical diagnostics, even in the last year #ECCMID2024 - maybe the techno-optimists will win out !
#ECCMID2024 Velu: optimised workflow for ID/AMR resp enrichment panel; simulated BAL matrix for controls; key importance of pre-analytical steps; differential effects on organism types - hard to find one process to cover all pathogens; likely need 2 processes depending on targets
#ECCMID2024 Vanhee: nice examples of targeted NGS for a variety of pathogens, inc fungi, NTM also HBV and HCV genotyping