Feel free to register and join online (or in person in Brisbane) for our latest genomics seminar UQ Medicine; industry partners presenting on new developments in clinical genomics - for both human and microbial applications Illumina Oxford Nanopore QIAGEN
eventbrite.com.au/e/uqccr-indust…

ESGEM.SG is launching a working group to develop standards for interpreting #AMR genotypes. Much like EUCAST guidance for interpreting lab phenotypes as S/I/R, we want to define the #AMR rules for interpreting genotypes. #ESCMIDGlobal2024

#ECCMID2024 Esther van Kleef: cluster RCT community-based bundle to reduce ESBL transmission in Burkina-Faso; 238 households, 4-5 per household; adjusted OR acquisition in intervention households vs non-intervention=1.23 [95% CI: 0.74 - 2.01]), so no clear effect alas

#ECCMID2024 Turner, DOTS RCT; dalbavancin vs SOC for complex SAB; DOOR scale as prim outcome 1-5 (5 =death); QoL score tie-breaker; 23 sites in N America, 200 randomised; included IVDU; balanced MSSA/MRSA; no difference in DOOR outcome but fewer AEs vs SOC

#ECCMID2024 Brett Mitchell: CLEEN study, stepped wedge RCT, 5,002 participants; cleaning bundle intervention associated with a significant reduction in HAIs, OR 0.61 (95%CI 0.47-0.81, p<0.001); cleaning of shared med equipment seems important, high baseline HAI rate (17%)

As her slide says, the scientifically successful companies are being destroyed economically. Pull incentives pay only for success, but finally, success will be rewarded.

New publication from Anna Maria Peri UQ News David Paterson UQ Medicine : Network meta-analysis including 25,682 patient events suggests rapid diagnostic tests may have mortality benefit when associated with effective antimicrobial stewardship pubmed.ncbi.nlm.nih.gov/38676943/

A study presented by Abdullah Tarik Aslan at #ESCMIDGlobal2024
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Is Pip-tazo-Teicoplanin use associated with increased risk for AKI?
David Paterson Patrick Harris

Kind of mind-bending the incredible progress being made in metagenomics-based clinical diagnostics, even in the last year #ECCMID2024 - maybe the techno-optimists will win out !

#ECCMID2024 Interesting workflow for pathogen detection from blood DZD #DZD using ultra high enrichment process, reportedly even at very low CFU/mL, claiming zero false pos; with machine-learning based AST prediction, VME <1.5%, CA>95% impressive stuff

#ECCMID2024 Velu: optimised workflow for ID/AMR resp enrichment panel; simulated BAL matrix for controls; key importance of pre-analytical steps; differential effects on organism types - hard to find one process to cover all pathogens; likely need 2 processes depending on targets

#ECCMID2024 Vanhee: nice examples of targeted NGS for a variety of pathogens, inc fungi, NTM also HBV and HCV genotyping