Orian Shirihai and I are immensely proud of Byourak Shabane for winning 3rd poster price for her presentation at the UCLA #Mitochondria Symposium. She's not on Twitter but cheer for her and get ready for great things to come! Aspiring #SCIENTIST #scicomm

Mitoquinone mesylate targets SARS-CoV-2 and associated lung inflammation through host pathways biorxiv.org/content/10.110…. #COVID19 #SARSCoV2 #COVID #Covid_19 #OmicronVarient

Very excited to present the results of our continuing collaboration between Orian Shirihai and Theodoros Kelesidis labs. Madhav Sharma and I (with a lot of help!) studied whether a mitochondria-targeted antioxidant Mitoquinone can inhibit SARS-CoV-2 infection. biorxiv.org/content/10.110…

What are mitochondria? If you thought they were just the powerhouse of the cell, think again. A tour-de-force paper by Martin Picard and Orian Shirihai published today in Cell Metabolism argues that they should be considered the processor of the cell cell.com/cell-metabolis…

Check our new publication: ATP hydrolysis by CV occurs in healthy mitochondria and is increased in mitochondrial diseases. Thank you for an incredible teamwork Rebeca Acin Perez, Cris Beninca, Marc Liesa Christoph Gerle, Karel Erion, Cristina Ghenoiu and Ruchi Masand

We identified a compound that binds the IF1 groove of ATP Synthase and inhibits ATP hydrolysis. In cells with impaired respiratory function, inhibition of ATP hydrolysis by CV can increase cellular ATP content even without restoring respiratory function embopress.org/doi/full/10.15…

The EMBO Journal Most exciting, the extent of ATP hydrolysis is reciprocal to loss of muscle force in a Duchenne Muscular Dystrophy model. Inhibition of ATP hydrolysis (red dots) prevents loss of muscle force. embopress.org/doi/full/10.15…

Thank you, Jenny Ngo, for this cool cartoon

We reveal a new mechanism whereby mitochondrial morphology determines cellular fuel preference and fatty acid oxidation capacity by altering CPT1 sensitivity to inhibition by Malonyl-CoA in liver, islet, and lymphoma The EMBO Journal doi.org/10.15252/embj.…

This study provides a mechanism by which fatty acids take over the control of insulin secretion from glucose, leading to dysregulated insulin secretion (hyper-secretion) and insulin resistance; a phenomenon described by Barbara Corkey Prentki and Jim Johnson, PhD

Exciting coast-to-coast collaboration UCLA & Dana-Farber! Thank you Jenny Ngo (Jennifer), DongWook Choi & Nika Danial. We describe the downstream effector of mitochondrial morphology in regulating fatty acid utilization The EMBO Journal doi.org/10.15252/embj.…

Thank you Marc Liesa Ilan Benador-Shen, MD, PhD Anthony Molina Nate Miller and Linsey Stiles for contributing to the development of this concept and for a great collaboration. Thank you Jenny Ngo for drawing this cartoon. Note the cristae, Wimpy, and the snowman.

Fernandez-del-Rio et al. demonstrate a Novel Approach to Measure Complex V ATP Hydrolysis in Frozen Cell Lysates and Tissue Homogenates. Orian Shirihai life-science-alliance.org/content/6/4/e2…

The 6th Annual Mitochondria Symposium UCLA will take place on Dec 7th-9th. Full 3 days, including unconventional Mito activities. With 30 invited speakers and panelists. Registration & abstract submission: uclamitosymposium.com

I am happy to announce that I will be guest editing a special issue in IJMS focusing entirely on the exciting new topic of lipid droplet and mitochondria interactions. Please consider submitting your exciting new results to our special issue: mdpi.com/journal/ijms/s…