Dr. Jason Stein's lab (Jason Stein) at UNC-Chapel Hill determined the cross-site reproducibility of human cortical #organoid 🧫 (hCO) differentiation using three independent research groups to assay hCOs in multiple differentiation replicates. StemCellReports | bit.ly/4dDxaiJ

Core regulatory 🧬 genes were screened using the TCGA database, and the expression of neurexophilin 4 (NXPH4) and its prognostic implications was validated using tissue microarray staining using cellular, #organoid, and 🐭 murine models. 🔗 bit.ly/3T72iP4

🧫 Scientists developed an #organoid model of cholangiocarcinoma co-cultured with TAMs that can shorten the model construction cycle and preserve the heterogeneity of original #tumors to improve the accuracy of 💊 drug screening. Heliyon | bit.ly/3XmiKhb

🔎 Investigators with Dr. Erica Carolina at IMSUT, The University of Tokyo developed a novel 3D co-culture method that successfully established functional human #bile ducts by emulating liver #epithelial-blood vessel interaction. Learn more at 👉 Nature Communications | go.nature.com/3ZnC0wj

🔬 Investigators developed a novel method for two-dimensional-cultured #hepatic differentiation from primary human #hepatocytes-derived 🧫 #organoids by screening several compounds, cytokines, and growth factors. iScience journal | bit.ly/475NLZS

🧪 Intestinal #organoids were grown in normal and high glucose media to study the impact of hyperglycemic stress on the intestinal barrier. Learn more from this Cleveland Clinic Lerner Research Institute research team led by Dr. Carol de la Motte and Samreen Jatana. 👉 bit.ly/3Ms1jWi

Dr. Tyler J Wenzel at U of Saskatchewan has developed a one-of-a-kind cerebral #organoid model from human stem cells, aiming to revolutionize #Alzheimers diagnosis and treatment. 🧫 🔗 bit.ly/3APQTgr

A review that is not to be missed! ✨ Dr. Benjamin Dwyer and Nina Tirnitz-Parker GAICD 🧬🔬 discuss state-of-the-art patient-derived liver #organoid models, recent technological advancements, and strategies to enhance their clinical impact. Curtin University Trends in Endocrinology & Metabolism | bit.ly/47nexgJ

Some absolutely fascinating insights! Congratulations to the whole team! 🎊

To distinguish viral versus proinflammatory-macrophage-mediated β cell pyroptosis, Weill Cornell Medicine scientists, including Dr. @LiuliuYang1, developed hPSC-derived vascularized #macrophage-islet organoids. bit.ly/4gqAcJ1

Using intestinal organoids, researchers reported that #hyperglycemic environments directly compromise intestinal epithelial barrier function in an organoid model and hyaluronan protects via a layilin dependent mechanism. bit.ly/3Ms1jWi

🧠 Drs. Dionne, Sabatié, and Laurent at Université de Sherbrooke provides an overview of how 3D brain organoids have been used to investigate various neurodevelopmental disorders, including #FragileXSyndrome and Rett syndrome, and elucidate their pathophysiology. bit.ly/3AXoWDx

📰 Global life science and 3D biology company Molecular Devices has launched a new life sciences facility in Cardiff, dedicated to research, development, and industrial-scale manufacture of organoids. bit.ly/3Zo4bv3

🔬 Dr. Tania Hübscher and researchers at EPFL identified conditions enabling 🐭 mouse thymic epithelial progenitor cell proliferation and development into #organoids with diverse cell populations and transcriptional profiles! Development | bit.ly/3Zp79zr

A novel 3D intestinal 🧫 #organoid model was utilized to investigate that exposure to triclosan/triclocarban led to a compromised self-renewal and differentiation of #intestinal stem cells. 📖 Journal of Hazardous Materials |Letters |Advances | bit.ly/3ZeYwr1

🔬 Researchers at Philipps-Universität systematically investigated the neutral lipid–synthesizing enzymes diacylglycerol O-acyltransferases and the sterol O-acyltransferase 1 in orthoflavivirus #infection using cell culture models and cerebral #organoids. Communications Biology | go.nature.com/3ARck0x

In this study, scientsits showed that phosphorylation of 53BP1 at serine 25 by ATM was required for 🧠 #neural progenitor cell proliferation and neuronal differentiation in cortical brain #organoids. Find out more at 👉 PLOS Biology | bit.ly/4gfhBQ1

🧫 The authors describe a human alveolus microphysiological system model of primary human #alveolar epithelial and lung microvascular endothelial cells to study infection with #SARSCoV2 at a Biosafety Level 3 facility. 🔗 bit.ly/3B1vAIU 📰 bit.ly/47pD4lh

The authors investigated the susceptibility of camelids to #SARSCoV2 using novel well-differentiated camelid 👃 nasal organoids. 👇 Find out if the #organoids were more susceptible to certain coronaviruses over others. 👓 go.nature.com/4d8G7PH

👓 Learn all about the mechanisms of PM2.5-induced neurotoxicity! Investigators constructed 3D cortical #organoids that faithfully recapitulated the initial stages of human 🧠 cerebral cortex development to investigate. 🔗 bit.ly/3XncB30