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Organoid News

@organoidscience

An online resource for researchers studying and using organoids. Part of the @STEMCELLTech Science News service.

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linkhttp://organoidnews.com calendar_today26-09-2017 19:07:55

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Organoids Are Us is a symposium to report and discuss the latest advances in #organoids to tackle unanswered biological and clinical questions. 📆23-26 September 2025 📍Glasgow, Scotland Only two weeks left to submit your abstract. Register now! 👇 bit.ly/4nrFZRN

Organoids Are Us is a symposium to report and discuss the latest advances in #organoids to tackle unanswered biological and clinical questions.

📆23-26 September 2025
📍Glasgow, Scotland

Only two weeks left to submit your abstract. Register now! 👇
bit.ly/4nrFZRN
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🧫Dr. Sandra Petrus-Reurer's team at NIHR Cambridge Biomedical Research Centre used co-cultures and humanized mouse experimental models to examine autologous and allogeneic immune responses to human primary cholangiocyte organoids as treatment for bile duct disorders. Cell Reports Medicine | bit.ly/3IxJtT0

🧫Dr. Sandra Petrus-Reurer's team at <a href="/CambridgeBRC/">NIHR Cambridge Biomedical Research Centre</a> used co-cultures and humanized mouse experimental models to examine autologous and allogeneic immune responses to human primary cholangiocyte organoids as treatment for bile duct disorders.

<a href="/CellRepMed/">Cell Reports Medicine</a> | bit.ly/3IxJtT0
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👀 Dr. Brian Hafler's team at Yale School of Medicine obtained viable short-interval postmortem human retinal tissue and generated human retinal organoids that contain electrophysiologically active neurons. Science Advances | bit.ly/4lDtUI6

👀 Dr. Brian Hafler's team at <a href="/YaleMed/">Yale School of Medicine</a> obtained viable short-interval postmortem human retinal tissue and generated human retinal organoids that contain electrophysiologically active neurons.

<a href="/ScienceAdvances/">Science Advances</a> | bit.ly/4lDtUI6
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Researchers led by Drs. Pranavkumar Shivakumar & Jorge Bezerra from UT Southwestern Medical Center show that modulation of TGF-β-dependent EMT regulates bile duct epithelial development. 🔓 More here: go.nature.com/4lCfVSF

Researchers led by Drs. Pranavkumar Shivakumar &amp; Jorge Bezerra from <a href="/UTSWMedCenter/">UT Southwestern Medical Center</a> show that modulation of TGF-β-dependent EMT regulates bile duct epithelial development.

🔓 More here: go.nature.com/4lCfVSF
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🔉 Organoid researchers, check out this The EMBO Journal article about kidney organoids! Scientists established a chemically defined, serum-free protocol for prolonged culture of human fetal kidney-derived organoids in vitro. 💡 Learn more: bit.ly/3II8jzK

🔉 Organoid researchers, check out this <a href="/embojournal/">The EMBO Journal</a> article about kidney organoids! 

Scientists established a chemically defined, serum-free protocol for prolonged culture of human fetal kidney-derived organoids in vitro. 

💡 Learn more: bit.ly/3II8jzK
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In this new Cancer Gene Therapy study, researchers found a link between APC mutation type, #organoid maturation, and FAP severity. They show that rapamycin rescues APC-mutated colon organoid differentiation. 🧫 More here: go.nature.com/4muH3TZ

In this new <a href="/cgtnature/">Cancer Gene Therapy</a> study, researchers found a link between APC mutation type, #organoid maturation, and FAP severity.

They show that rapamycin rescues APC-mutated colon organoid differentiation. 🧫

More here: go.nature.com/4muH3TZ
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Dr. Ann Parr and team developed 3D-printed #organoid scaffolds for transplantation using clinically relevant hiPSC-derived regionally specific spinal neural progenitor cells. U of M Neurosurgery 📖 Learn more about spinal organoids: bit.ly/44NljN2

Dr. Ann Parr and team developed 3D-printed #organoid scaffolds for transplantation using clinically relevant hiPSC-derived regionally specific spinal neural progenitor cells. <a href="/umnneurosurgery/">U of M Neurosurgery</a>

📖 Learn more about spinal organoids: bit.ly/44NljN2
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This review summarizes recent protocols that have been developed to generate human microglial-containing cerebral #organoids, focusing on the methods used to assess the level of microglial maturation compared to their in vivo counterparts. 🧠 👉 bit.ly/4mbvL6z

This review summarizes recent protocols that have been developed to generate human microglial-containing cerebral #organoids, focusing on the methods used to assess the level of microglial maturation compared to their in vivo counterparts. 🧠

👉 bit.ly/4mbvL6z
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There are only a few days left to submit your abstract for a chance to present your research to an international audience at Organoids Are Us 2025. 📆23 - 26 September 2025 📍Glasgow, Scotland Find out more about the invited speakers and program here: bit.ly/4lGeToY

There are only a few days left to submit your abstract for a chance to present your research to an international audience at Organoids Are Us 2025.

📆23 - 26 September 2025 
📍Glasgow, Scotland

Find out more about the invited speakers and program here: bit.ly/4lGeToY
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🧫 Dr. Guebum Han and researchers at University of Minnesota developed 3D-printed organoid scaffolds for transplantation using clinically relevant human induced pluripotent stem cell-derived regionally specific spinal neural progenitor cells. 👉 bit.ly/44NljN2

🧫 Dr. <a href="/GuebumH/">Guebum Han</a> and researchers at <a href="/UMNews/">University of Minnesota</a> developed 3D-printed organoid scaffolds for transplantation using clinically relevant human induced pluripotent stem cell-derived regionally specific spinal neural progenitor cells.

👉 bit.ly/44NljN2
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🧫 This study introduces a colon organoid model valuable for studying colorectal cancer and developing new diagnostic, preventive, and therapeutic approaches to prevent or delay tumorigenesis in familial adenomatous polyposis patients. 👉 go.nature.com/4muH3TZ

🧫 This study introduces a colon organoid model valuable for studying colorectal cancer and developing new diagnostic, preventive, and therapeutic approaches to prevent or delay tumorigenesis in familial adenomatous polyposis patients.

👉 go.nature.com/4muH3TZ
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🚨Become an expert on using #organoids in drug discovery with STEMCELL Technologies! Stay up-to-date with current applications, new products, insights from key opinion leaders, and more: bit.ly/3QSfIwU

🚨Become an expert on using #organoids in drug discovery with <a href="/STEMCELLTech/">STEMCELL Technologies</a>!

Stay up-to-date with current applications, new products, insights from key opinion leaders, and more: bit.ly/3QSfIwU
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🧫 Researchers employed a digital light processing system to perform 3D bioprinting of a DNA-silk fibroin hydrogel sustained-release system with BMSCs to construct millimeter-scale cerebral #organoids. Military Medical Research | bit.ly/472GNa4

🧫 Researchers employed a digital light processing system to perform 3D bioprinting of a DNA-silk fibroin hydrogel sustained-release system with BMSCs to construct millimeter-scale cerebral #organoids.

<a href="/MMR_Journal/">Military Medical Research</a> | bit.ly/472GNa4
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👂 Scientists developed a cochlear organoid culture system using synthetic GelMA hydrogel, thereby accelerating organoid formation and facilitating the functional maturation of cochlear hair cells. ACS Nano | bit.ly/44SUHZS

👂 Scientists developed a cochlear organoid culture system using synthetic GelMA hydrogel, thereby accelerating organoid formation and facilitating the functional maturation of cochlear hair cells.

<a href="/acsnano/">ACS Nano</a> | bit.ly/44SUHZS
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🧫 Scientists developed a novel liver multilineage organoid model combined with Mdr2-/- mice to investigate the pro-fibrotic role of T helper 17 cells for primary sclerosing cholangitis. 🔓 Journal of Nanobiotechnology | bit.ly/4l8sgx1

🧫 Scientists developed a novel liver multilineage organoid model combined with Mdr2-/- mice to investigate the pro-fibrotic role of T helper 17 cells for primary sclerosing cholangitis.

🔓 <a href="/JNanobiotech/">Journal of Nanobiotechnology</a> | bit.ly/4l8sgx1
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🎯 Researchers developed CAR-T cells targeting B7-H3 and evaluated their anti-tumor activity in vitro and in vivo, using patient-derived organoids and xenograft models to validate their translational potential. British Journal of Cancer | go.nature.com/4fjx0yI

🎯 Researchers developed CAR-T cells targeting B7-H3 and evaluated their anti-tumor activity in vitro and in vivo, using patient-derived organoids and xenograft models to validate their translational potential.

<a href="/BrJCancer/">British Journal of Cancer</a> | go.nature.com/4fjx0yI
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Researchers describe #organoid cultures derived from pig foliate taste papillae in which the cellular heterogeneity of the lingual epithelium is preserved. 💡 Learn more in Endocrine Society: bit.ly/4lgdTXE

Researchers describe #organoid cultures derived from pig foliate taste papillae in which the cellular heterogeneity of the lingual epithelium is preserved.

💡 Learn more in <a href="/TheEndoSociety/">Endocrine Society</a>: bit.ly/4lgdTXE
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Dr. Elly Hol's team at UMC Utrecht found that mutations in GFAP can severely affect neural #organoid development through altering lineage commitment in embryoid bodies. GFAP plays a role as an early modulator of neurodevelopment. 🧠 bit.ly/40PH6RS

Dr. Elly Hol's team at <a href="/UMCUtrecht/">UMC Utrecht</a> found that mutations in GFAP can severely affect neural #organoid development through altering lineage commitment in embryoid bodies.

GFAP plays a role as an early modulator of neurodevelopment. 🧠 

bit.ly/40PH6RS
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How can intestinal #organoid models be used as tools to interrogate the physiology of human mucosal tissues and host-microbe interactions? 💡 Learn from this review: bit.ly/47kamnC

How can intestinal #organoid models be used as tools to interrogate the physiology of human mucosal tissues and host-microbe interactions? 

💡 Learn from this review: bit.ly/47kamnC
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Using patient-derived #ColorectalCancer (CRC) organoids and functional assays, researchers investigated the role of stromal-secreted Wnt5a. Wnt5a suppresses CRC progression via TGF-β/NOTUM/OLFM4 axis in patient-derived #organoids. 👉 bit.ly/45pmnFF

Using patient-derived #ColorectalCancer (CRC) organoids and functional assays, researchers investigated the role of stromal-secreted Wnt5a. 

Wnt5a suppresses CRC progression via TGF-β/NOTUM/OLFM4 axis in patient-derived #organoids.

👉 bit.ly/45pmnFF