
Organoid News
@organoidscience
An online resource for researchers studying and using organoids. Part of the @STEMCELLTech Science News service.
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http://organoidnews.com 26-09-2017 19:07:55
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🧫Dr. Sandra Petrus-Reurer's team at NIHR Cambridge Biomedical Research Centre used co-cultures and humanized mouse experimental models to examine autologous and allogeneic immune responses to human primary cholangiocyte organoids as treatment for bile duct disorders. Cell Reports Medicine | bit.ly/3IxJtT0


👀 Dr. Brian Hafler's team at Yale School of Medicine obtained viable short-interval postmortem human retinal tissue and generated human retinal organoids that contain electrophysiologically active neurons. Science Advances | bit.ly/4lDtUI6


Researchers led by Drs. Pranavkumar Shivakumar & Jorge Bezerra from UT Southwestern Medical Center show that modulation of TGF-β-dependent EMT regulates bile duct epithelial development. 🔓 More here: go.nature.com/4lCfVSF


🔉 Organoid researchers, check out this The EMBO Journal article about kidney organoids! Scientists established a chemically defined, serum-free protocol for prolonged culture of human fetal kidney-derived organoids in vitro. 💡 Learn more: bit.ly/3II8jzK


In this new Cancer Gene Therapy study, researchers found a link between APC mutation type, #organoid maturation, and FAP severity. They show that rapamycin rescues APC-mutated colon organoid differentiation. 🧫 More here: go.nature.com/4muH3TZ


Dr. Ann Parr and team developed 3D-printed #organoid scaffolds for transplantation using clinically relevant hiPSC-derived regionally specific spinal neural progenitor cells. U of M Neurosurgery 📖 Learn more about spinal organoids: bit.ly/44NljN2




🧫 Dr. Guebum Han and researchers at University of Minnesota developed 3D-printed organoid scaffolds for transplantation using clinically relevant human induced pluripotent stem cell-derived regionally specific spinal neural progenitor cells. 👉 bit.ly/44NljN2



🚨Become an expert on using #organoids in drug discovery with STEMCELL Technologies! Stay up-to-date with current applications, new products, insights from key opinion leaders, and more: bit.ly/3QSfIwU


🧫 Researchers employed a digital light processing system to perform 3D bioprinting of a DNA-silk fibroin hydrogel sustained-release system with BMSCs to construct millimeter-scale cerebral #organoids. Military Medical Research | bit.ly/472GNa4



🧫 Scientists developed a novel liver multilineage organoid model combined with Mdr2-/- mice to investigate the pro-fibrotic role of T helper 17 cells for primary sclerosing cholangitis. 🔓 Journal of Nanobiotechnology | bit.ly/4l8sgx1


🎯 Researchers developed CAR-T cells targeting B7-H3 and evaluated their anti-tumor activity in vitro and in vivo, using patient-derived organoids and xenograft models to validate their translational potential. British Journal of Cancer | go.nature.com/4fjx0yI


Researchers describe #organoid cultures derived from pig foliate taste papillae in which the cellular heterogeneity of the lingual epithelium is preserved. 💡 Learn more in Endocrine Society: bit.ly/4lgdTXE


Dr. Elly Hol's team at UMC Utrecht found that mutations in GFAP can severely affect neural #organoid development through altering lineage commitment in embryoid bodies. GFAP plays a role as an early modulator of neurodevelopment. 🧠 bit.ly/40PH6RS


