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Expanding cells so much you can directly see and hold them : this is why more research projects should take introductory schoolbook statements ("human cells are too small to see without a microscope") and figure out ways to prove them wrong.

Spatial-omics goes 3D🤗! Out at Cell Cell 👉🏼 We developed DISCO-MS with Matthias Mann Lab, a spatial proteomics technology for specimens fully imaged in 3D. DISCO-MS is aided by robotics and enables the study of diseases at their early stages. cell.com/cell/fulltext/…🧵👇

Time-tagged ticker tapes for intracellular recordings go.nature.com/3i84I0S

Whoever invented the Jan 5 NIH deadline needs to be brought up on charges for crimes against humanity

Do you have limited access to microscopes? Well, now you can view cells with the naked eye. 👀 Here I reported on how this could be done at little cost. "This technique is a gamechanger." - Manu Prakash #Microscopy Ons M'Saad The Scientist the-scientist.com/news-opinion/n…

Our latest work is a #bioRxiv double feature: Endoplasmic reticulum tubules are ellipsoidal thanks to the nanoscale organization of Rtn4 oligomers (biorxiv.org/content/10.110……)! Lukas Fuentes Zach Marin Jonathan Tyson, Ph.D. David Baddeley Yale Cell Biology #er #ellipsoidaler and...

I'll be at poster board #463 between 1.45 and 2.45pm today if you want to hear about expansion microscopy and fluorescent NHS ester labelling of cellular compartments! #BPS2023

Unclearing microscopy: seeing human cells directly by eye. 👀 Two more #preLights are now online! Rob Mahen highlights an amazing #preprint from Ons M'Saad, Michael Shribak & Bewersdorf Lab which introduces a promising new technique: #UnclearingMicroscopy 👉 prelights.biologists.com/highlights/unc…

🚨Science Magazine paper alert🚨 Our Optical Nanoscopy Department pushed the #MINFLUX technique to the next level. It now allows protein dynamics to be observed under physiological conditions with a spatio-temporal precision of one nanometer/millisecond. bit.ly/3mGRuKn

Out in Science Magazine today: We used MINFLUX to measure stepping of kinesin in living cells in 2D and 3D. Very cool work spearheaded by Takahiro Deguchi in my group in collaboration with @KapiteinLukas and Malina Iwanski in Utrecht. science.org/doi/10.1126/sc…

ÅNGSTRÖM-RESOLUTION FLUORESCENCE MICROSCOPY. Can we do structural biology with an optical microscope? Yes! Check out how we resolved *single bases of DNA* and much more using fluorescence microscopy, out today in nature! nature.com/articles/s4158… Jungmann Lab Max Planck Institute of Biochemistry (MPIB)

The treatment and prevention of Hyperemesis Gravidarium (HG), the severe vomiting & illness experienced by some pregnant women, is now possible. Thrilled that teams led by the brother (below) have discovered the cause of such a debilitating condition. Well done, Steve & Co.

Check out our new study in Science Magazine, where we take on a 100-year-old debate: what’s the role of aneuploidy in cancer? We discovered that genetically removing extra chromosomes blocks cancer growth - a phenomenon we call “aneuploidy addiction”. science.org/doi/10.1126/sc…

The human fallopian tube, a beautifully complex multicellular structure. Using CODA, we map the fallopian tube in 3D and at single-cell resolution. Here is a best projection of the 3D annotated stack of just vasculature and epithelium. More here: biorxiv.org/content/10.110…

Robust and scalable single-molecule protein sequencing with fluorosequencing, Erisyon Inc. biorxiv.org/content/10.110…

Our new preprint on a probabilistic multi-fidelity #climate model parameterization to extrapolate to unseen warmer climates is out! Moving towards better climate change projections with #ArtificialIntelligence Liran Peng Mike Pritchard Pierre Gentine arxiv.org/abs/2309.10231

Our new CMAME paper on scalable Bayesian optimization with randomized prior networks is out! The method accounts for constrained multi-fidelity optimization tasks & is applied to compressor's blades shape optimization in turbo-machinery. Paris Perdikaris sciencedirect.com/science/articl…

A great day for RNA, and for groundbreaking science performed at biotech companies! #NobelPrize

New explanation for infertility: eggs lacking a mysterious ‘lattice’ go.nature.com/3sgspJh

Please check out our (Bewersdorf Lab) latest work on #FLASHPAINT published in Cell. #FLASHPAINT builds on #DNAPAINT and allows for fast and fluorogenic, highly multiplexed super-resolution imaging. cell.com/cell/fulltext/…