Direct attachment of a cleavable linker onto peptides and proteins in ionic liquid with a Wittig reaction precursor, published in Chemical Communications! Good job, Zeinab Nizam et al! pubs.rsc.org/en/content/art…

Excited to share the lab's first paper J. Am. Chem. Soc.: Ultra-rapid Electrophilic Cysteine Arylation pubs.acs.org/doi/full/10.10…

New KFB Lab Member Alert (1 of 4): We warmly welcome Elizabeth Gross (@elizabe301) who comes to us from the Ohata Lab NC State Chemistry! Very excited to see her go from bioconjugation to biocatalysis!

Small molecules that release CO2 enhance bioconjugation in ionic liquids! Work by our undergrad Brandon, published in one of the Synlett Clusters ‘Chemical Tools for Peptide Modifications’ Chemistry at Thieme thieme-connect.de/products/ejour…

Friedel-Crafts alkylation becomes rapid Trp-selective catalysis in HFIP for radio-/antibody-labeling! With ionic liquid, HFIP maybe biomolecule-compatible. Work by Mohammad Nuruzzaman et al. with Zibo Li (UNC)/Elon Ison/佐藤伸一 published J. Am. Chem. Soc.! doi.org/10.1021/jacs.3…

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Our review "Friedel-Crafts reactions for biomolecular chemistry" has been published in OBC! Mechanisms of each reaction are shown in the SI too. doi.org/10.1039/D4OB00…

Vincent Lindsay (@TheLindsayLab) presents his talk “Sulfonylcyclopropanols as Modular Cyclopropanone Equivalents” in our next #ThiemeCheminar on April 24, 2024, at 6:00 PM (CEST). Secure your seat now! 👉 brnw.ch/21wIW0m

New JCE ASAP article! We surveyed industry chemists from 80 companies about the undergraduate instrumentation experience / skill development that best prepared them for chemical industry. Happy first pub day to David Hamilton and Alyssa Castillo! pubs.acs.org/doi/10.1021/ac…

KFB Lab Alert: Congratulations to Elizabeth Gross on her News & Views Article Nature Synthesis covering a pair of fantastic reports on a new biocatalytic strategy for radical fluorination by Peng Liu Group, Yang Yang, Yunfang Yang, Marc Garcia-Borràs, Xiongyi Huang-JHU Biocatalysis!

Many bioconjugation methods started using fluoroalcohols TFE and HFIP. Check out our review by Mohammad Nuruzzaman Zeinab Nizam published in Tetrahedron Chem as part of their special issue "Biomolecule Synthesis and Modification". doi.org/10.1016/j.tche…

Our metal-free tryptophan labeling paper by Mohammad Nuruzzaman and Brandon Colella is published in RSC Chemical Biology as part of the Emerging Investigators collection! Cell lysate modification in HFIP was compared with aqueous lysine and cysteine modification. doi.org/10.1039/D4CB00…

The beginning of a professor job can be difficult. Fortunately for Jun, Laura (laura4acs.org) has been in the same department, providing great support and wisdom. You wouldn’t regret voting for her for the ACS president! (Please repost this to support her if possible!)

Serine has diverse roles in living systems, but development of serine labeling tools has been a challenge. Our work published ChemEurJ: Chemistry - A European Journal achieved chemoselective serine acylation in an unbiased manner! doi.org/10.1002/chem.2…

Our collaborative review paper with the Kounosuke OISAKI | 生長 幸之助 & Sato labs about catalysis of protein bioconjugation was published ChemCatChem See how 7 types of catalysis were used for modification of proteins! doi.org/10.1002/cctc.2…

Our writing method CASPArS is available in Japanese now! We thank Chem-Station to make this happen. Hope this will be helpful for Japanese learners. Original article: pubs.acs.org/doi/10.1021/ac…

A cyclic peptide found in meteorite may undergo mechanochemical reactions with formaldehyde! The first prebiotic chemistry paper from our group published in ACS Bio&Med Chem Au. doi.org/10.1021/acsbio…