Our collaboration with the lab of Tomoo Ogi is now online in Cell! Ubiquitylation of RNAPII regulates DNA repair and protects against persistent stalling and neurodegeneration! cell.com/cell/fulltext/…

The DDR continues to amaze me. Wonderful work! Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair: Cell cell.com/cell/fulltext/…

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair #GFP #immunoprecipitation #ubiquitin cell.com/cell/fulltext/…

Struikelblok op DNA lijkt oorzaak van zeldzame #Cockayne syndroom. Lees meer over dit onderzoek van Martijn Luijsterburg 👇 lumc.nl/over-het-lumc/… Amy and Friends, NL

Single site ubiquitination of RNA Pol II at Lys1268 controls UV-induced DNA damage response. Looks like a very fundamental mechanism in biology!

In the latest issue: #ubiquitination of #RNA polymerase promotes recruitment of TFIIH and initiation of #transcription-coupled #repair whose dysregulation in mice cause neurological consequences #CockayneSyndrome bit.ly/394lkft

In the latest issue: #OpenAccess control of pool of available #RNA polymerase II shapes how #cells respond to #UV stress and the efficacy of resulting #damage response bit.ly/3ddzVs7

Here is some shutdown reading while you are trying to relax on your couch at home: A preview I wrote with Kook Son on two papers from the Ogi and Svejstrup laboratories on how RNAPII ubiquitination affects transcription and repair cell.com/cell/fulltext/….

Published yesterday! Surviving DNA damage requires more than just repairing DNA damages - a dramatic regulation of the transcriptome, via a novel modification of RNA Pol II. You can read about our work here (open access!): cell.com/cell/fulltext/…

#AMED 名大オミックス解析拠点から #コケイン症候群 の病態理解につながる論文がCell誌に報告されました。転写共役修復の開始反応の分子メカニズムの一端が明らかになりました。 amed.go.jp/news/release_2… med.nagoya-u.ac.jp/medical_J/rese…

#AMED Multi-omics Analysis Centre at Nagoya University has just published a paper describing molecular pathogenesis of #Cockayne syndrome. Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair cell.com/cell/fulltext/…

washingtonpost.com/graphics/2020/…

🌸🌸At least the cherry blossoms are not cancelled on our campus 🌸🌸

Orlando D. Schärer Very beautiful! The cherry blossoms in our street are also in bloom!