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"Grafted organoids reveal how microglia adapt to shifting brain environments" “What they show is exciting,” Florent Ginhoux says. “But it is really just the beginning.” Thank you Spectrum (Autism Research News) for featuring our study. Thanks, @realFlorentGinhoux!

I am delighted to share that my postdoc work is now out in Science Magazine. We investigated the resident #macrophage #KupfferCell compartment in liver #fibrosis and made some surprising observations! (1/17) science.org/doi/10.1126/sc…

📣Our paper is out 🥳 ➡️ nature.com/articles/s4158… We discovered that IDH2-mediated reductive carboxylation of glutamine epigenetically dictates effector T cell differentiation.

Excited and proud to have been part of this amazing work with @realFlorentGinhoux ... with a mesmerizing reviewing process .

🥼 Dr. Floren Ginhoux (@realFlorentGinhoux) and team at A*STAR Research generated #microglia-sufficient #brain organoids by 🧫 coculturing brain #organoids with primitive-like #macrophages generated from the same human induced pluripotent stem cells. 🔗 bitly.ws/ZhAv

We are glad we could contribute to this great work. iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer nature.com/articles/s4158…

French, Singaporean and British researchers, led by Prof. @realFlorentGinhoux, head of a research team at Gustave Roussy - Inserm, have succeeded in demonstrating in a neuronal organoid the role of the brain's immune environment in its formation and development. 🔗gustaveroussy.fr/en/neural-orga…

New paper alert‼️ #ImmunoMetabolismPower #EpigeneticPower! Excited to share our latest paper showing that host-derived oxidized phospholipids produced in response to pathogen encounter initiate effector-triggered immunity & cause the death of the host 1/9 biorxiv.org/content/10.110…

Given their persistence, we wondered where reprogrammed neutrophils were located. With a combination of 10x Genomics Visium and Miltenyi Biotec MACSima imaging, we traced reprogrammed neutrophils to a unique hypoxic-glycolytic niche 🗺️. Location matters! (7/16)

Excited to share our new paper Science Magazine All credit goes to my (ex)team members Melissa Ng Immanuel Kwok #LeonardTan #Changming. Special thanks to Andrés Hidalgo, @realFlorentGinhoux and Renato Ostuni for their continuing support and friendship

Exploring the Future of Child Health: How Tailored Prenatal Vitamin D Supplementation Based on Maternal Diet Patterns Boosts Offspring Bone and Dental Well-being #PrenatalCare #VitaminDSupplementation #ChildHealth COPSAC Rick M Kim mdpi.com/2072-6643/16/3…

Here’s the big one: In collaboration with Alf Honigmann, Shevchenko Lab, Björn Drobot and Martin Hof we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. biorxiv.org/content/10.110…

I think I have shared this already but this is indeed a fantastic piece of extremely elegant cell biology with profound potential implications in development, physiology and disease science.org/doi/10.1126/sc…

Preclinical data reveal that dietary fat sources differentially regulate natural killer and CD8 T cell infiltration and function within the tumour microenvironment, governed by distinct effects on the plasma metabolome and intracellular metabolism. nature.com/articles/s4225…

Neurons and astrocytes have distinct organelle signatures and responses to stress dlvr.it/TN7bvJ

Nature research paper: Structural basis for mTORC1 activation on the lysosomal membrane go.nature.com/3VRBZxp

Endoplasmic reticulum junctions serve as a platform for endosome-lysosome interactions through their stop-and-go motion switching | Science Advances science.org/doi/10.1126/sc…

Drs. Dirk Görlich and Steven McKnight have won the 2025 Albert Lasker Award for Basic Medical Research for showing that low-complexity domains of proteins lack structure on their own and yet can form assembled states essential to cellular functions. Learn more in the Clinical