Nicolas Villain Our point of view in one slide (also with the idea of extending the concept beyond AD):

ncbi.nlm.nih.gov/books/NBK60593…

Our committee is unable to recommend lecanemab for treating mild cognitive impairment or mild dementia caused by Alzheimer’s disease. Benefits of slowing disease progression, by 4-6 months on average, can not justify the high cost to the NHS. Learn more: nice.org.uk/news/articles/…

🚨The Great Debate in Diagnosing Alzheimer Disease: More Than Just a β Test🚨in my accompanying Editorial Neurology Journal as supported by the excellent & necessary collaborative study led by Eduardo Zimmer Zimmer Lab et al! Special thx to Melissa Paretsky! dx.doi.org/10.1212/WNL.00…

"The [biomarker only] guidelines were the only guidelines that did not significantly predict future cognitive decline" or dementia ➡️ Biomarkers are great but: Not perfect Not a diagnosis Not to be used in isolation, no matter what folks w conflicts of interest say

🚨 Available as a preprint – The Alzheimer's Association #pTau round robin study 🚨 📣 33 different ways to measure #blood #pTau 📣 Mass Spec, semi & fully-auto immunoassays 📣 #pTau217 consistently best 📣 Corr. between assays = optimism for standardisation medrxiv.org/content/10.110…

Using a novel PET tracer for imaging inflammation, Appleton et al. show that people with mild cognitive impairment with onset before the age of 65 years show brain inflammation that co-localizes with tau and correlates with cognitive impairment. tinyurl.com/2v6n2nrf

This Clinical/Scientific Note reports a case of fatal super-refractory status epilepticus associated with amyloid-related imaging abnormalities (#ARIA): bit.ly/4fVZnm7 #NeuroTwitter

I totally agree with Simon Mead. Perhaps Alberto J Espay will attend the upcoming conference secure.qgiv.com/event/mechanis… where we will discuss such issues based on scientific data. I would be curious to listen to Alberto J Espay and be allowed to challenge his incomprehensible conclusions.

Vision Impairment and the Population Attributable Fraction of Dementia in Older Adults jamanetwork.com/journals/jamao… via Jennifer Anne Deal et al Robert Howard Andrew Lees Seb Walsh Lon S. Schneider, MD Nicolas Villain Madhav Thambisetty Jason Cohen Kariem Ezzat Alberto J Espay shibley

Ischemic stroke associated with amyloid‐related imaging abnormalities in a patient treated with lecanemab - Gibson - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…