Loved hearing about this from Pedro Rocha when I visited NIH (now BioRxiv): -Heterozygous deletion of CTCF insulator is lethal -Deletion of single CTCF motif is lethal -Mech: single CTCF motif loss->aberrant E-P->expression of Fgf genes -CTCF matters! biorxiv.org/content/10.110…

🚨🚨New Preprint!🚨🚨 2nd postdoc paper by Shreeta Chakraborty who is on the job market 🔥👀🔥 We asked whether perturbing TADs that have many developmental regulators can cause very severe phenotypes and the answer was clear: biorxiv.org/content/10.110…

Really awesome work by Pedro Rocha on the role of CTCF insulator sites near the FGF3/4 cluster! So exited to see this out! #CTCF #3Dgenome #Epigenetics

Our lab (papantonislab.eu) is still looking for a PhD candidate with a strong computational biology background and a keen interest for genome assembly and #3Dgenomics to join our subproject in the exciting EvoREST initiative on genome evolution. Universitätsmedizin Göttingen (UMG) Uni Göttingen

This is a cool conference poster✨ eventsignup.ku.dk/argonautes2024

Our preprint describing how #developmental genes and #CTCF clusters cooperate in the robust #insulation of regulatory #domains just got published in Nature Communications rdcu.be/dRMcN

Have you ever wondered about how the genomic position of regulatory elements impact their functional output? Check out our latest pre-print from the @bvanssteensellab. biorxiv.org/content/10.110…

1/23 We are excited to announce that our most recent study “In vivo dendritic cell reprogramming for cancer immunotherapy” was published in Science Magazine. science.org/doi/10.1126/sc… Here is a summary of what we discovered!

I'm excited to share this collaborative work with Katerina Kraft and Matt Jones that started as an exploration of the nuclear organization of ecDNA in colon cancer cells and ended with some neat findings on repetitive elements. See thread for more!

Spectacular work fearlessly spearheaded by Narlikar/Ramani & Tetrad graduate student Camille Moore; check out & RT Camille's thread below describing her efforts to characterize chromatin condensation & some ways it can be regulated; bioRxiv here: biorxiv.org/content/10.110…

Check out a recent review from the Larson lab, where Chris explores in depth how enhancers communicate with their target genes, and the effect this has on transcriptional bursting.

My lab is hiring a postdoc, don't hesitate to apply! Lots of opportunities to work on Hi-C/Micro-C and super-resolution imaging in Drosophila and mESCs.

(1/n) From Viraat Goel Ed Banigan et al. collab w blobellab Leonid Mirny biorxiv.org/content/10.110… RCMC at the M-to-G1 transition reveals strong microcompartments between CREs (E,P) in mitosis, that weaken upon G1 entry Sims reveal chromosome compaction as key regulator