We discovered a new immune signaling molecule: N7-cADPR N7-cADPR is produced by phage-stimulated TIR proteins. It activates a bacterial caspase, which then degrades essential proteins to curb infection Preprint: biorxiv.org/cgi/content/sh… Congrats @FrancoisRousset & Ilya Osterman

I'm thrilled to announce our latest work is now published in Cell! Viruses encode numerous proteins that inhibit host defenses, but identifying immune-modulatory proteins among millions of viral sequences has been nearly impossible - until now! cell.com/cell/fulltext/…

Very happy our paper on CARD domains in gasdermin anti-phage defense systems is now published in nature 🥳 Thanks to all the people involved especially the Kranzusch lab and Sorek Lab nature.com/articles/s4158…

Our paper out nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems CARDs are essential for caspase recruitment in inflammasome activation. We now find them in bacterial immune systems Congrats Tanita Wein! Thanks Kranzusch lab! tinyurl.com/CA88DD

Now published Science Magazine: TIR signaling activates caspase-like immunity in bacteria We report a new immune molecule: N7-cADPR. Produced by phage-induced TIRs and activates a defensive bacterial caspase Congrats @FrancoisRousset & Ilya Osterman! science.org/doi/10.1126/sc…

It’s out! Read my review with Sorek Lab on the nucleotide pool as a central playground in antiviral immunity across humans, bacteria and plants! 🧍‍♀️🦠🌿 & the diverse ways in which viruses overcome these nucleotide-based immune mechanisms 🗡️ nature.com/articles/s4157…

📢 Preprint out! Together with Renee Chang and the amazing Sorek Lab , we explored viral sponges to map their diversity and function. Discovered huge diversity, including sponges that inhibit Pycsar & Type IV Thoeris! biorxiv.org/content/10.110…