Our paper, “Programming multicellular assembly with synthetic cell adhesion molecules” is now online ahead of print. nature.com/articles/s4158… @nature @ucsf Cell Design Institute @UCSF Fletcher Lab (and Andrew Harris), Faranak Fattahi Ophir Klein Josiah Gerdts Wesley McKeithan

Check out our paper Science Magazine. We engineered synthetic T cell circuits that locally produce the cytokine IL2. Specific configurations of IL2 circuits dramatically improved T cell clearance of solid tumors without systemic toxicity. Cell Design Institute @UCSF #SynBio science.org/doi/10.1126/sc…

I’m hiring a postdoc to join my new lab in Stanford Genetics! I’m looking for a creative and team-oriented postdoc to engineer receptors and gene circuits to control immune cells and hematopoietic stem cells for therapeutic applications. Plz retweet 🙏🏾 1/n

Excited to receive my PhD from UCSF! Grateful for the opportunity to do science and be surrounded by so many incredible people over the years! #UCSFgrad

We are delighted to announce a $30M contract with ARPA-H (ARPA-H) to develop the next generation of tissue-targeted cellular therapies. Foci of the project include precision therapeutics for glioblastoma, multiple sclerosis, and Alzheimer's disease. ucsf.edu/news/2024/04/4…

So excited to announce that the Kappel Lab will open at UCLA UCLA Chem & Biochem in July 2025! We’ll combine high-throughput experiments and computation to build predictive sequence-structure-function models of RNA, proteins, and their interactions. More here: sites.google.com/view/kappellab/

The next frontier of T cell therapeutics when the T also stands for tissue-targeting, such as brain or local immune response, via synthetic gene circuits Science Magazine science.org/doi/10.1126/sc… science.org/doi/10.1126/sc… science.org/doi/10.1126/sc…

From suppressing unwanted immunity to inducing immunity where it counts, SynNotch-engineered T cell can carry diverse payloads to specific locations, allowing for customized effects in numerous treatments bit.ly/4gfNUh8 DrMilosSimic Cell Design Institute @UCSF Parker Institute for Cancer Immunotherapy Nish Reddy

Now online! Synthetic organizer cells guide development via spatial and biochemical instructions dlvr.it/TGv5Jv

New from Drs. Nish Reddy, Wendell Lim, and others at Cell Design Institute @UCSF! They engineered human T cells to make a synthetic receptor recognizing overactive T cells that can #AutoimmuneDisease and #OrganRejection. 📃Science Magazine: bit.ly/3ZLzWwA 🎧: bit.ly/3BCg72H

#ScienceSaturday Treating #neurological disorders like #brain tumors is difficult in part due to a protective “wall” called the blood-brain barrier, meant to block toxins from reaching brain cells. ➡️ In this study, DrMilosSimic, Nish Reddy, Et al. developed brain-sensing T

I am excited to announce that in March, I will start my lab in the Department of Cancer Biology (Univ. of Pennsylvania Department of Cancer Biology) at the University of Pennsylvania Perelman School of Medicine (Penn Medicine). Stevens.bio

We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their

It's official - I am thrilled to share that I am joining MIT Biology, the Koch Institute at MIT, and MIT IMES as an Assistant Professor this fall! We will be a hybrid lab combining new technologies and computation to study ecDNA and tumor evolution. thejoneslaboratory.com

Can we use RNA to insert kilobases of DNA into the human genome, opening up a new way to engineer cells or treat disease? Excited to share our latest work turning a retrotransposon (a “jumping gene” with an RNA intermediate) from songbirds into a genome editing tool. 🧵 (1/7)