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Everyone needs to at least glance at figure 2 of this amazing paper 🌟😍 P300’s C-terminal domain (where the very interesting TAZ2 domain is within) binds chromatin more than the catalytic core alone. Really fundamental stuff for gene regulation.

Our paper describing TCIP1 is out, with some notable additions, including an examination of transcription elongation, and an insightful perspective by Jim Phelan and Lou Staudt on what this new modality could do in lymphoma. nature.com/articles/d4158… nature.com/articles/s4158…

Check out Renee’s pre-print 📄❗️ especially fig 6. Lots of surprising design principles that could be used towards engineering TF specificity.

Wonderfully written review. I think we will come up with better functional classes of effector domains once we can comprehensively map all the cofactor interactions

📜 Happy to share our recent preprint featuring ORFtag - a versatile, easy and cost-effective method for probing protein function at a proteome scale. This work is the result of a collaborative effort by the StarkLab, Stefan L Ameres, Ulrich Elling and @juliusbrennecke labs. 1/2

Great continuation of Uri Alon’s “How to choose a good scientific problem”

Do you really need to spread plasmid libraries on mountains of plates to get uniform growth, or can you just dump them in a flask and call it a day? We make huge plasmid libraries in the de Boer Lab, so we tested whether culture method really matters. 1/ biorxiv.org/content/10.110…

Excited to share new work from Garrett Ginell in which we present an approach for predicting intermolecular interaction driven by disordered regions. We focus on how chemical complementarity can contribute to and even dictate intermolecular interactions biorxiv.org/cgi/content/sh…

Do human RNA-binding proteins have modular regulatory domains that downregulate RNA lifetimes? Our preprint Bintu Lab studying this question is now out on bioRxiv, where we indeed identify small domains in RBPs that potently induce RNA degradation! biorxiv.org/content/10.110… (1/9)

The DelRosso Lab is starting UC San Francisco 1/2025 and is seeking applicants for a research postbac! We will be developing cutting edge high-throughput approaches to study the relationship between disordered protein interactions and transcription in human cells🔎 aprecruit.ucsf.edu/JPF05341

Our work using thermodynamic principles to link in vitro TF affinities and kinetics to single-molecule chromatin states in cells is now on bioRxiv! Amazing effort by first author juliaschaepe in William J. Greenleaf lab: biorxiv.org/content/10.110… Stanford University SciLifeLab Stockholm University [1/9]