Our study led by SUN CONGXIN & Dr. Elena Seranova with @VIKorolchuk, funded by Wellcome & LifeArc, on loss of #autophagy depleting #NAD to cause cell death of human neurons, having implications for #ageing and #neurodegeneration, is out now in Cell Reports cell.com/cell-reports/f…

A big thank you to our organisers Sovan Sarkar @VIKorolchuk for a fantastic meeting &thank you to the speakers and poster presenters for great participation &discussion.Wishing you all a safe journey home and #watchthisspace for next years meeting announcements! #AtgUK23 #AtgUK24

Thank you Sovan Sarkar and @VIKorolchuk for organising an excellent meeting #AtgUK23!

Since the discovery of CRISPR-Cas systems, people have wondered if a similar type of system exists in eukaryotes. Today, we report in nature the characterization of Fanzor, a eukaryotic RNA-guided system that can be reprogrammed for human genome editing. nature.com/articles/s4158…

💛 Last week marked a historic moment for us at VitaDAO and for the entire field of longevity science. 💫 We launched our VITA-FAST tokens, creating the first-ever opportunity for token holders to directly influence longevity research. 🌐 🧵 longevity.technology/news/vitadao-l…

Thank you #nldconf2023 for a great event!

Come and join our lab!

Pleased to share my first review paper, published in BioEssays, on the evolution of selective autophagy receptors. Thanks to co-first author Tetsushi Kataura, as well as Gisela Otten and @VIKorolchuk onlinelibrary.wiley.com/doi/full/10.10…

Update! We develop MitoPQ to measure mitochondrial proteostasis: Identify biphasic role for UPRmt to protect and then repair proteostasis. Metabolic hubs and ribosome highly reliant on UPRmt. Mitophagy steps in when UPRmt can't take care of business. science.org/doi/10.1126/sc…

Super exciting to see our work featured on the cover of EMBO Reports The artform illustrates that CML cells require uptake of extracellular arginine for survival Shout-out to Kevin Rattigan for leading the experimental work and Hanna Salmonowicz for the amazing art design 🩸🎨

Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe nature.com/articles/s4158…

🏆 Without further ado, let's give a round of applause to the WINNERS of YES23! 🥳🏅 Your contributions have truly made a mark, and we can't wait to see the impact your ideas will have on the world. 🌍💡 #YES #InnovationCelebration #Congratulations #NextGenLeaders 🚀🌟

Thank you #YES2023 for a hugely inspiring experience!

It’s finally happened. A peer-reviewed journal article with what appear to be nonsensical AI generated images. This is dangerous.

Mitochondrial H2O2 release does not directly cause damage to chromosomal DNA | Nature Communications nature.com/articles/s4146…

Happy to share our new paper published in Cell Death & Disease! We showed either FDA-approved autophagy activating drugs or orally bioavailable NAD precursors can promote cell survival including neurons in Niemann-Pick Type C disease models. rdcu.be/dJBSz

Women are born with all their oocytes, which need to stay viable for decades to ensure fertility. How are they maintained for that long? Our latest research in Nature Cell Biology reveals that oocyte maintenance involves exceptional protein longevity. nature.com/articles/s4155… (1/9)

Congrats to all authors 👏 it was a pleasure to be involved!

We are offering a #PhD project for MIBTP funded PhD Studentship [warwick.ac.uk/fac/cross_fac/…] on #autophagy, cell survival, human stem cells, neurons, cerebral organoids. Deadline 16/01/2025, open to worldwide students including UK & EU, apply here [warwick.ac.uk/fac/cross_fac/…]

📢Excited to introduce NanoCas -our new mini CRISPR system that can reach tissues previously out of reach! By shrinking CRISPR to 1/3 its normal size, we can now edit genes in muscle, heart & brain that were difficult to access before. Summary & link to paper: