The Paradox Institute is officially tax-exempt!! With our approved 501(c)(3) status, we can now pursue grants and tax-deductible donations from individuals and foundations to help us produce reality-based science education on a grand scale. Thank you so much to all who have

This is unbelievable! Well done to Zachary Elliott & Cynthia Breheny for all their relentless hard work in getting this sorted!

This is only a review on sex differences in fluid biomarkers in Alzheimer’s disease, but it highlights a crucial and often overlooked point: sex differences can manifest in multiple and unexpected ways. For example, some biomarkers may show clear sex differences in their overall

Politically extreme individuals (whether far left or far right) show similar brain patterns when viewing political content

New paper examines hippocampal subfield volumes in FtMs on long-term testosterone therapy compared to female controls. It reports a larger right subiculum and some voxel-wise right hippocampal differences. These findings are interpreted as potential structural effects of chronic

Define both “gender identity” and “woman,” then lay out the criteria for implicating a brain region or network. Does it have to be sex-atypical? Tied to a specific function, or something broader? How would we test that? And what would count as good evidence?

What do you think is the biggest challenge in discussing the neurological sex differences literature online?

If males can identify as women, then that, in effect, abolishes women as a sex class. If that is not an existential threat, I do not know what is.

Watching the Mind & Body seminars at “New Science Live” (New Scientist) at London Excel. Very interesting:

Which physical structure holds gender identity?

Neuroimaging evidence indicates that feminizing hormone therapy (estrogen + anti-androgen) in transgender women is consistently associated with a reduction in global brain volume and accompanied by ventricular enlargement. This pattern is interpreted as reflecting