Most popular read this week: Findings from a large dataset paint a vivid picture of posterior cortical atrophy—including when it begins, the primary symptoms, and the pathological proteins involved: bit.ly/3SZXV90 #NeuroTwitter @AANMember

This just published online in the Headache journal. Overwhelming evidence and clinical experience supporting the use of these transformative therapies as first-line approaches.

1/Time to rupture all your misconceptions about aneurysms! When you see an aneurysm on imaging, do you know it’s risk of rupture? Do you know which features make one aneurysm more likely to rupture? Here’s a short thread to teach you which aneurysms are bursting with risk!

Does dopamine replacement affect cognitive (thinking) function in Parkinson's? Is it all about the motor? Guess what folks, Semiller, Pontone and Mills teach us about the aspects of cognition that 'change' on and off dopamine replacement therapy. Key Points: - The authors point

In two decades of anti-amyloid trials in #Alzheimers (2002-2023), placebo emerges as the historic winner. Do No Harm: #Lecanemab is an accident, not a victory. Presented today at #ASENT, Bethesda, ASENT.org.

Case report: the evaluation of a 44-year-old man with a history of headache, dizziness, and imbalance and imaging that showed lacunar infarctions and bilateral white matter hyperintensities. ja.ma/49L8P8J

31 year-old man with confusion and slowed movements a few days after ingesting home-made liquor. MRI showed these strange lesions (left side is ADC). Diagnosis?

Our first Continuum issue on headache since 2021 publishes… next week! Very excited for this issue. The amazing Dr. Amy Gelfand has put together an awesome list of topics and authors ⬇️ Much has changed in the world of headache, you won’t want to miss this one

This case expands on the current knowledge of KLHL11-related autoimmune encephalitis including the paraneoplastic presentation, associated tumor types, and management of this syndrome in women: bit.ly/4ak2lNU #NeurologyRF #NeuroTwitter

In pediatric-onset multiple sclerosis, initiating highly-effective rather than moderately-effective therapies may better control early disease activity and expose patient to less discontinuation due to inefficacy and intolerance. ja.ma/48Jw2GU

33 year old male presents with seizure. MRI reveals a brain tumor as shown. Can you make the WHO CNS 2021 diagnosis on this single image?

If you have hallucinations, psychosis or paranoia with Parkinson and your clinician has tried all options short of medication, this is the key table you will need with the big 3 choices you should limit your team to using. We are seeing too many folks turn to atypical and typical

Case report: a 17-year-old boy with reduced consciousness and T2-weighted hyperintensity, focal diffusion restriction, and microhemorrhages within the deep gray nuclei and surrounding white matter. ja.ma/49wJfDm

Most viewed in the last 7 days from JAMA Neurology: This narrative review describes the phenotypes of anti-GQ1b antibody syndrome to aid in its diagnosis in light of its various clinical presentations. ja.ma/44W5u4Y

This is one of the largest meta-analyses on the effects of exercise on cognitive performance. Here are my top 4 evidence-based protocols from it to leverage exercise to maximize cognitive performance. 1/13

Wish you had a sixth sense to localize that sixth cranial nerve palsy? Feeling six feet under when you see a sixth nerve deficit? Here’s a cheat sheet to help you locate the lesion in a sixth cranial nerve palsy! Just remember the Six Syndromes of the Sixth Cranial Nerve!

Have you seen this syndrome? Mineralizing lenticulostriate vasculopathy and traumatic infarction? Basal ganglia involvement and NO movement disorder. Great case in Annals of Neurology American Neurological Association by Li and colleagues. Key Points: - A 14 you had loss of consciousness. - Then a

Anyone can get multiple sclerosis. This study found that for women in the Netherlands with the "lowest 30% genetic risk," they still had a 1 in 2,739 risk of MS (vs. 1 in 92 for women with the top 10% genetic risk). pubmed.ncbi.nlm.nih.gov/39270152/

In this study, fecal microbiota transplantation (FMT) was safe, but did not improve Parkinson disease (PD) symptoms more than placebo. Improvements and microbiome changes after placebo warrant further research on FMT and bowel cleansing in PD. ja.ma/4d0DcJ7

Results from two large, prospective studies suggest that dementia in Parkinson disease occurs less frequently, or later in the disease course, than previous research studies have reported: bit.ly/4dYBzg5 #NeuroTwitter